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Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Torres AE and Luk KM declared that there are no conflicts of interest; Lim HW is an investigator for
Incyte, L’Oréal, Pfizer, PCORI, has served as consultant for Pierre Fabre, ISDIN, Ferndale, and Galderma,
and has participated as a speaker in general educational session for Johnson & Johnson, and Ra Medical
System.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

REFERENCES
1. Parrado C, Mascaraque M, Gilaberte Y, Juarranz A, Gonzalez S. Fernblock (Polypodium leucotomos extract): molecular mechanisms and
pleiotropic effects in light-related skin conditions, photoaging and skin cancers, a review. Int J Mol Sci 2016;17:1026.
2. Krutmann J, Passeron T, Gilaberte Y, Granger C, Leone G, et al. Photoprotection of the future: challenges and opportunities. J Eur Acad
Dermatol Venereol 2020;34:447-54.
3. Yeager DG, Lim HW. What’s new in photoprotection: a review of new concepts and controversies. Dermatol Clin 2019;37:149-57.
4. Schneider SL, Lim HW. Review of environmental effects of oxybenzone and other sunscreen active ingredients. J Am Acad Dermatol
2019;80:266-71.
5. Schneider SL, Lim HW. A review of inorganic UV filters zinc oxide and titanium dioxide. Photodermatol Photoimmunol Photomed
2019;35:442-6.
6. Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, et al. Afamelanotide for erythropoietic protoporphyria. N Engl J
Med 2015;373:48-59.
7. Parrado C, Philips N, Gilaberte Y, Juarranz A, González S. Oral photoprotection: effective agents and potential candidates. Front Med
(Lausanne) 2018;5:188.
8. Saewan N, Jimtaisong A. Natural products as photoprotection. J Cosmet Dermatol 2015;14:47-63.
9. Lim HW, Arellano-Mendoza MI, Stengel F. Current challenges in photoprotection. J Am Acad Dermatol 2017;76:S91-9.
10. Gonzalez S, Lucena SR, Delgado P, Juarranz A. Comparison of several hydrophilic extracts of Polypodium leucotomos reveals different
antioxidant moieties and photoprotective effects in vitro. J Med Plants Res 2018;12:336-45.
11. Nestor MS, Berman B, Swenson N. Safety and efficacy of oral Polypodium leucotomos extract in healthy adult subjects. J Clin Aesthet
Dermatol 2015;8:19-23.
12. Kohli I, Shafi R, Isedeh P, Griffith JL, Al-Jamal MS, et al. The impact of oral Polypodium leucotomos extract on ultraviolet B response: a
human clinical study. J Am Acad Dermatol 2017;77:33-41.e1.
13. Granger C, Aladren S, Delgado J, Garre A, Trullas C, et al. Prospective evaluation of the efficacy of a food supplement in increasing
photoprotection and improving selective markers related to skin photo-ageing. Dermatol Ther (Heidelb) 2020;10:163-78.
14. Rabinovich L, Kazlouskaya V. Herbal sun protection agents: Human studies. Clin Dermatol 2018;36:369-75.
15. Mohammad TF, Kohli I, Nicholson CL, Treyger G, Chaowattanapanit S, et al. Oral Polypodium leucotomos extract and its impact on
visible light-induced pigmentation in human subjects. J Drugs Dermatol 2019;18:1198-203.
16. Zamarrón A, Lorrio S, González S, Juarranz Á. Fernblock prevents dermal cell damage induced by visible and infrared A radiation. Int J
Mol Sci 2018;19:2250.
17. Winkelmann RR, Del Rosso J, Rigel DS. Polypodium leucotomos extract: a status report on clinical efficacy and safety. J Drugs Dermatol
2015;14:254-61.
18. Farrar MD, Huq R, Mason S, Nicolaou A, Clarke KA, et al. Oral green tea catechins do not provide photoprotection from direct DNA
damage induced by higher dose solar simulated radiation: a randomized controlled trial. J Am Acad Dermatol 2018;78:414-6.
19. Nwanodi O. Skin protective nutraceuticals: the current evidence in brief. Healthcare (Basel) 2018;6:40.