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Torres et al. Plast Aesthet Res 2020;7:57                                    Plastic and
               DOI: 10.20517/2347-9264.2020.87                                   Aesthetic Research




               Review                                                                        Open Access


               Botanicals for photoprotection


               Angeli E. Torres, Kevin M. Luk, Henry W. Lim

               Photomedicine and Photobiology Unit, Department of Dermatology, Henry Ford Health System, Detroit, Michigan 48202, USA.

               Correspondence to: Dr. Henry W. Lim, Department of Dermatology, Henry Ford Hospital, 3031 West Grand Boulevard, Detroit,
               Michigan 48202, USA. E-mail: hlim1@hfhs.org

               How to cite this article: Torres AE, Luk KM, Lim HW. Botanicals for photoprotection. Plast Aesthet Res 2020;7:57.
               http://dx.doi.org/10.20517/2347-9264.2020.87

               Received: 20 Apr 2020    First Decision: 24 Aug 2020    Revised: 13 Sep 2020    Accepted: 29 Sep 2020    Published: 21 Oct 2020
               Academic Editor: Salvador Gonzalez    Copy Editor: Cai-Hong Wang    Production Editor: Jing Yu



               Abstract
               The importance of photoprotection against the deleterious effects of excessive and chronic exposure to sunlight is
               now well established. Photoprotective measures include behavioral modifications such as seeking shade, wearing
               photoprotective clothing, wide-brimmed hat and sunglasses, and applying sunscreen to exposed areas. Data
               on botanical topical and oral preparations have demonstrated photoprotective potential in in vitro, animal, and
               human studies. This review will focus on botanicals that have been most extensively studied, namely, Polypodium
               leucotomos extract, green tea, pomegranate, resveratrol, curcumin, and silymarin. These agents have shown
               promise in mitigating ultraviolet-induced acute changes on the skin, chronic photodamage, and even skin cancer
               prevention. However, it must be emphasized that current evidence indicates that these agents should be used
               as adjunctive measures rather than as a replacement of the photoprotective behavioral modifications described
               above.

               Keywords: Botanical photoprotection, Polypodium leucotomos extract, green tea, pomegranate, resveratrol,
               curcumin, silymarin




               INTRODUCTION
               Electromagnetic radiation, including infrared, visible, and ultraviolet (UV) radiation (UVR), have both
               beneficial and harmful effects on the health of human skin. In particular, UVR exposure plays a significant
               role in the development of sunburns, photoaging, photoimmunosuppression, keratinocyte carcinomas,
               and cutaneous melanoma. They can also induce and exacerbate photosensitive dermatoses. Following



                           © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
                           International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
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