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Pignet et al. Plast Aesthet Res 2024;11:40 https://dx.doi.org/10.20517/2347-9264.2024.54 Page 5 of 14

Figure 1. PRISMA Flow Diagram. In total, 673 clinical publications elucidating the effects of FSG were identified. After elimination of
duplicates and non-eligible articles, eleven publications remained to be included. PRISMA: Preferred Reporting Items for Systematic
Reviews and Meta-Analyses; FSG: Fish skin grafts.

burn wound [14,18,19,23] . In the intervention groups, on the other hand, dressing changes of the NTG were only
performed when the product did not adhere properly to the wound and/or the secondary dressing was
soaked in exudate.

In a pilot study conducted by Lima Júnior et al., patients with SPTB up to 10% of TBSA were included . In
[19]
the control group, treated with an absorbent silver dressing (Aquacel® Ag, ConvaTec, Skillman, NJ),
dressing changes were mandatory, following the manufacturer’s recommendation . The total number of
[19]
dressings was significantly reduced (P < 0.001) in the NTG-treated group compared to the control group .
[19]
In a phase two clinical trial, Lima Júnior et al. divided the patients into three groups: Group A consisted of
out-patients with SPTB covering less than 10% of TBSA; Group B included in-patients with SPTB covering
10%-20% of TBSA; Group C comprised in-patients with deep partial-thickness burns covering 5%-15% of
[14]
TBSA . In the control group (silver sulfadiazine cream 1%), a dressing change was performed every 24 h in
groups B and C, and every 48 h in group A . In the NTG-treated groups, a significantly lower number of
[14]
dressing changes was observed (P < 0.0001) .
[14]