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Topic: Adopt One Health, Stop

                                                  Rabies: Current Progress for

                                                  Dog-mediated Rabies Elimination

                                                  by 2030





                                                  Rabies is an acute, progressive, viral encephalitis. This zoonosis
                                                  is one of the oldest recognized infectious diseases but remains
           Charles E. Rupprecht                   neglected despite a global distribution. Although all mammals
                                                  are believed to be susceptible, the domestic dog is the major
             Auburn University, Auburn,           reservoir. Having a case fatality approaching unity, humans still
                      AL, USA                     succumb today due to major health disparities, particularly in
                                                  less developed regions in Asia, Africa, and the Americas. In 2015,
                  CEO, Lyssa LLC                  the FAO, OIE, and WHO recognized the need for a focused One

                                                  Health approach dedicated to the elimination of human rabies by
                  Expert Technical
                Advisor on Rabies for             2030. Known as ‘Zero by Thirty’ (ZBT), this initiative focuses
                  the PAHO/WHO                    on stopping human fatalities caused by rabid dog bites through
                                                  modern  postexposure  prophylaxis (PEP)  and  controlling  the
                 Chief of the Rabies              virus  at its source via the mass  vaccination of dogs  (MVD).
                  Program at CDC                  This Special Issue of One Health & Implementation Research
                                                  (OHIR) showcases the progress made over the past decade,
                Director of the WHO               anticipates continued success, discusses current limitations, and
               Collaborating Center for           highlights future opportunities expected. Key areas of relevance
                Reference & Research              include enhanced laboratory-based rabies surveillance, improved
                      on Rabies
                                                  PEP regimens, better community engagement, technology for
                   Head of the OIE                monitoring MVD success, oral vaccination for free-ranging dogs,
                  Rabies Reference                creation of local champions, prioritization by relevant governance,
                     Laboratory                   inter-sectoral collaboration with regional partners, and engagement
                                                  of global  stakeholders. Given the  trans-disciplinary  nature of
                                                  this arena, we invite all animal control officers, anthropologists,
                                                  diagnosticians, economists, epidemiologists, historians, modelers,
                                                  physicians,  policy  makers,  veterinarians,  virologists,  wildlife
                                                  biologists, and others passionate about achieving the ZBT to
                                                  communicate their work in OHIR.
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