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Page 10 Bozzetti et al. Neuroimmunol Neuroinflammation 2021;8:1-13 I http://dx.doi.org/10.20517/2347-8659.2020.26

biomarkers. Recent data on the presence of axonal damage also in patients with antibodies targeting
astrocytes (AQP4-Abs) or oligodendrocytes (MOG-Abs) further extend the possible use of this biomarker
in quantifying disease activity in these conditions, although their role in predicting disease course and
long-term prognosis in these disorders has yet to be clarified.

DECLARATIONS
Authors’ contributions
Analysis and interpretation of data and drafting the manuscript: Bozzetti S, Ferrari S, Gajofatto A
Design and conceptualization of the review, analysis and interpretation of data, and drafting the
manuscript: Mariotto S
Read and approved the final manuscript: Bozzetti S, Ferrari S, Gajofatto A, Mariotto S

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2021.

REFERENCES
1. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald
criteria. Lancet Neurol 2018;17:162-73.
2. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, et al; International Panel for NMO Diagnosis. International consensus
diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015;85:177-89.
3. Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, et al; International Pediatric Multiple Sclerosis Study Group. International
Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system
demyelinating disorders: revisions to the 2007 definitions. Mult Scler 2013;19:1261-7.
4. Petzold A, Plant GT. Diagnosis and classification of autoimmune optic neuropathy. Autoimmun Rev 2014;13:539-45.
5. Transverse Myelitis Consortium Working Group. Proposed diagnostic criteria and nosology of acute transverse myelitis. Neurology
2002;59:499-505.
6. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water
channel. J Exp Med 2005;202:473-7.
7. Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol 2019;15:89-102.
8. Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, et al. Neurofilament light chain as a biomarker in neurological disorders. J
Neurol Neurosurg Psychiatry 2019;90:870-8.
9. Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, et al; Swiss Multiple Sclerosis Cohort Study Group. Serum neurofilament light:
a biomarker of neuronal damage in multiple sclerosis. Ann Neurol 2017;81:857-70.
10. Gaiottino J, Norgren N, Dobson R, Topping J, Nissim A, et al. Increased neurofilament light chain blood levels in neurodegenerative
neurological diseases. PLoS One 2013;8:e75091.
11. Mattsson N, Cullen NC, Andreasson U, Zetterberg H, Blennow K. Association between longitudinal plasma neurofilament light and
neurodegeneration in patients with alzheimer disease. JAMA Neurol 2019;76:791-9.