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Breis et al. Neuroimmunol Neuroinflammation 2020;7:330-4 I http://dx.doi.org/10.20517/2347-8659.2020.14 Page 331

Figure 1. It represents CASPR2 localization at the juxta-paranodal portion in the node of Ranvier, showing its interaction with
Contactin-2 forming the voltage gated potassium chanel complex (VGKC complex)

Figure 2. Shows the variety of clinical phenotypes involving the anti-CASPR2 antibodies and it’s overlapping between central and
peripheral nervous system syndromes

in the expression, especially in the inhibitory interneurons in the hippocampus [6,8,9] . This may cause
[8]
[11]
hyperexcitability that could cause epilepsy and network imbalance supported by neuroimaging studies .
[12]
Morvan’s syndrome is an autoimmune disease that affects CNS, PNS and autonomic system . It consists
[13]
of neuromyotonia (cramps, stiffness, fasciculation) , encephalopathy, insomnia, dysautonomic signs