Page 25 - Read Online

Page 4 of 5 Wu et al. Neuroimmunol Neuroinflammation 2019;6:4 I http://dx.doi.org/10.20517/2347-8659.2019.07

secreted by human adipose tissues, and has multi-mechanisms protective against cerebral ischemic injury, it
is of great potential in the application of clinical treatment of ischemic stroke in the future.

DECLARATIONS
Acknowledgments
The author is grateful to Prof. Mao-Tsun Lin, Prof. Chao-Ching Huang, and Prof. Chun Y. Hsu for
mentoring, and colleagues of Chi Mei Medical Center, and team members of Taiwan Stroke Biosignature for
support.

Authors’ contributions
Wu MH is responsible for design and conceptualization of the study, drafting and revising the manuscript,
and obtaining funding.

Availability of data and materials
Not applicable.

Financial support and sponsorship
This study was supported by grants from Chi Mei Medical Center (CMNCKU9908), Chi Mei Medical
Center, Liouying (CLFHR10607), and Academia Sinica Taiwan Stroke Biosignature Project (AS-BD-108-11).

Conflicts of interest
The author declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

REFERENCES
1. Yamauchi T, Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated
regulation of metabolic and cardiovascular diseases. Int J Obes (Lond) 2008;32:S13-8.
2. Wu MH. Obesity, adiponectin and prognosis of ischemic stroke from bench to beside - basic and clinical studies. Taiwan: National
Cheng Kung University; 2017. p. 111.
3. Bloemer J, Pinky PD, Govindarajulu M, Hong H, Judd R, et al. Role of adiponectin in central nervous system disorders. Neural Plast
2018;2018:4593530.
4. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/
adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 2003;278:9073-85.
5. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, et al. Impaired multimerization of human adiponectin mutants associated with diabetes.
Molecular structure and multimer formation of adiponectin. J Biol Chem 2003;278:40352-63.
6. Yamauchi T, Kadowaki T. Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell Metab
2013;17:185-96.
7. Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by
monocytic cell line THP-1. Endocrinology 2005;146:790-6.
8. Guerre-Millo M. Adiponectin: an update. Diabetes Metab 2008;34:12-8.
9. Zhu W, Cheng KK, Vanhoutte PM, Lam KS, Xu A. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic
intervention. Clin Sci (Lond) 2008;114:361-74.
10. Caselli C, D’Amico A, Cabiati M, Prescimone T, Del Ry S, et al. Back to the heart: the protective role of adiponectin. Pharmacol Res
2014;82:9-20.
11. Hui X, Lam KS, Vanhoutte PM, Xu A. Adiponectin and cardiovascular health: an update. Br J Pharmacol 2012;165:574-90.
12. Trujillo ME, Scherer PE. Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern