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Neuroimmunol Neuroinflammation 2019;6:15 I http://dx.doi.org/10.20517/2347-8659.2019.019 Page 23 of 24

be elucidated. Here we proposed that changes in the brain that occur early in the AD pathology may
lead to this higher susceptibility to epileptogenesis. Disruption in brain’s glutamate homeostasis has been
reported in both disease and therefore it has the potential to link the two diseases together. This study
aimed to explore the potential role of glutamate in the pathogenesis of acquired epilepsy in AD. It also
aimed to identify potential early biomarkers or a diagnostic tool for acquired epilepsy in AD. Six month-
old Tg2576 AD mice along with their wild-type (WT) littermate were utilised in this study. The cortex
and the hippocampus were extracted from the animal, then western blotting and mass spectrometry were
performed. Tg2576 had significantly lower amounts of GLT-1 and Glutamine synthetase in the cortex,
compared to the WT. Additionally, mass spectrometry have shown that metabolites such as glutamate and
glutamine have the potential to be the early biomarker for acquired epilepsy in AD. The results suggest
that the astrocytic function could be impaired early in AD and this include the glutamate-glutamine cycle.
This impairment might lead to a higher susceptibility of the brain to epileptogenesis via the excessive
extracellular glutamate. The findings from the metabolomics analysis also suggest that there are changes in
different brain’s metabolites early in AD.

32. Late preterm infants’ social competence, motor development, and cognition

Jia You, Hong-JuanYang, Shi-Hui Ye, Jing-Jing Zheng

Early Child Development Center, Xi’an Maternal and Child Health Care Hospital, Xi’an, Shaanxi, China

A preterm birth with a GA of 34 weeks 0 days to 36 weeks 6 days is called a late preterm birth; 70% of
preterm births fall into this gestation period. Until a few years ago, late preterm birth was considered of
no importance in the regular monitoring of babies’ health, neurodevelopment, and social development.
The aim of this study was to compare the social competence, motor development, and cognition of late
preterm infants (LPIs) with full-term infants. Several studies in the recent past indicated that LPIs are at
high risk of social development problems. We compared the development of motor skills, cognition, and
social competency of LPIs with full-term infants at between 2 and 2.5 years old. The Chinese versions of
the Gesell development diagnosis scale and the normal development of social skills from infants to junior
high school children scale were used for the assessment. LPIs were not more socially competent than their
full-term counterparts. Each skill, namely adaptability, gross motor, fine motor, language, and personal-
social responses, was separately associated with the total level of social skills. It was found that gross motor
skills had a positive correlation with the self-help and locomotive abilities, and fine motor skills had a
positive association with locomotion abilities. LPIs had risk factors due to their delayed social skills in
areas including motor disorders and physiological and perinatal factors. LPIs under three were at a higher
risk of impairment in social competency. Therefore, it is recommended that they be monitored regularly to
identify the development of social and cognitive disorders at an early stage.

33. The interaction of N-terminal motif of acetylcholinesterase and β-amyloid triggers

β-amyloid aggregation and deposition

Hao Wang, Yu Wang, Jian-Rong Xu, Li-Na Hou, Hao Wang, Hong-Zhuan Chen

Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine,
Shanghai, China

Acetylcholinesterase (AChE) is one of the molecular chaperones inducing β-amyloid (Aβ) aggregation and
deposition in the pathological process of Alzheimer’s disease (AD). Peripheral anionic site (PAS) of AChE is