Page 150 - Read Online
P. 150
Cellina et al. Neuroimmunol Neuroinflammation 2018;5:22 I http://dx.doi.org/10.20517/2347-8659.2018.15 Page 5 of 6
Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Reversal of
autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits.
Brain 2011;134:258-77.
8. Zhang J, Culp ML, Craver JG, Darley-Usmar V. Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic
stress in Parkinson’s disease. J Neurochem 2018;144:691-709.
9. Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH. Alterations in lysosomal and proteasomal markers in Parkinson’s disease:
relationship to α-synuclein inclusions. Neurobiol Dis 2009;35:385-98.
10. Dehay B, Bové J, Rodríguez-Muela N, Perier C, Recasens A, Boya P, Vila M. Pathogenic lysosomal depletion in Parkinson’s disease.
J Neurosci 2010;30:12535-44.
11. Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O’Kane CJ, Rubinsztein DC.
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington
disease. Nat Genet 2004;36:585-95.
12. Martin DDO, Ladha S, Ehrnhoefer DE, Hayden MR. Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci
2015;38:26-35.
13. Caviston JP, Holzbaur ELF. Huntingtin as an essential integrator of intracellular vesicular trafficking. Trends Cell Biol 2009;19:147-55.
14. Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky D,
Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS. Potential function for the Huntingtin protein as a scaffold
for selective autophagy. Proc Natl Acad Sci U S A 2014;111:16889-94.
15. Deng Z, Sheehan P, Chen S, Yue Z. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease? Mol Neurodegener
2017;12:90.
16. Shahheydari H, Ragagnin A, Walker AK, Toth RP, Vidal M, Jagaraj CJ, Perri ER, Konopka A, Sultana JM, Atkin JD. Protein quality
control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum. Front Mol Neurosci 2017;10:119.
17. Weishaupt JH, Hyman T, Dikic I. Common molecular pathways in amyotrophic lateral sclerosis and frontotemporal dementia. Trends
Mol Med 2016;22:769-83.
18. Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ.
Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis. Autophagy 2009;5:152-8.
19. Igci M, Baysan M, Yigiter R, Ulasli M, Geyik S, Bayraktar R, Bozgeyik İ, Bozgeyik E, Bayram A, Cakmak EA. Gene expression
profiles of autophagy-related genes in multiple sclerosis. Gene 2016;588:38-46.
20. Paunovic V, Petrovic IV, Milenkovic M, Janjetovic K, Pravica V, Dujmovic I, Milosevic E, Martinovic V, Mesaros S, Drulovic J, Trajkovic V.
Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients. J Neuroimmunol 2018;319:100-5.
21. Keller CW, Lünemann JD. Noncanonical autophagy in dendritic cells triggers CNS autoimmunity. Autophagy 2018;14:560-1.
22. Moloudizargari M, Asghari MH, Ghobadi E, Fallah M, Rasouli S, Abdollahi M. Autophagy, its mechanisms and regulation: implications
in neurodegenerative diseases. Ageing Res Rev 2017;40:64-74.
23. Patergnani S, Castellazzi M, Bonora M, Marchi S, Casetta I, Pugliatti M, Giorgi C, Granieri E, Pinton P. Autophagy and mitophagy
elements are increased in body fluids of multiple sclerosis-affected individuals. J Neurol Neurosurg Psychiatr 2018;89:439-41.
24. Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Sovak G,
Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by
Alzheimer-related PS1 mutations. Cell 2010;141:1146-58.
25. Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer’s
disease mice. J Neurosci 2008;28:8354-60.
26. Kalia LV, Lang AE. Parkinson’s disease. Lancet 2015;386:896-912.
27. Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 2004;1:14.
28. Jacobs AH, Tavitian B. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab 2012;32:1393-415.
29. Mankoff DA. A definition of molecular imaging. J Nucl Med 2007;48:18-21.
30. Wu C, Li F, Niu G, Chen X. PET imaging of inflammation biomarkers. Theranostics 2013;3:448-66.
31. Tronel C, Largeau B, Santiago Ribeiro MJ, Guilloteau D, Dupont AC, Arlicot N. Molecular targets for PET imaging of activated
microglia: the current situation and future expectations. Int J Mol Sci 2017;18:E802.
32. Ching AS, Kuhnast B, Damont A, Roeda D, Tavitian B, Dolle F. Current paradigm of the 18-kDa translocator protein (TSPO) as a
molecular target for PET imaging in neuroinflammation and neurodegenerative diseases. Insights Imaging 2012;3:111-9.
33. Hatori A, Yui J, Yamasaki T, Xie L, Kumata K, Fujinaga M, Fujinaga M, Yoshida Y, Ogawa M, Nengaki N, Kawamura K, Fukumura T,
Zhang MR. PET imaging of lung inflammation with [18F]FEDAC, a radioligand for translocator protein (18 kDa). PLoS One
2012;7:e45065.
34. Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M,
Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M. In vivo positron emission tomographic imaging of glial responses to amyloid-
beta and tau pathologies in mouse models of Alzheimer’s disease and related disorders. J Neurosci 2011;31:4720-30.
35. Edison P, Ahmed I, Fan Z, Hinz R, Gelosa G, Ray Chaudhuri K, Walker Z, Turkheimer FE, Brooks DJ. Microglia, amyloid, and glucose
metabolism in Parkinson’s disease with and without dementia. Neuropsychopharmacology 2013;38:938-49.
36. Cabral GA, Raborn ES, Griffin L, Dennis J, Marciano-Cabral F. CB2 receptors in the brain: role in central immune function. Br J
Pharmacol 2008;153:240-51.