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Figure 1. Comparison of the MAFLD and MASLD frameworks in addressing the coexistence of metabolic liver disease with other liver
diseases. This figure highlights the distinct approaches and features of each framework. The figure was created using Canva software.
MAFLD: Metabolic dysfunction-associated fatty liver disease; MASLD: metabolic dysfunction-associated steatotic liver disease;
MetALD: metabolic-alcoholic liver disease.

This review explores how the two definitions - MAFLD and MASLD - address the coexistence of MAFLD
with other liver conditions, including ALD and viral hepatitis. By highlighting the burden and prevalence of
these overlaps, we aim to examine their strengths and challenges in accurately reflecting the complexity of
fatty liver disease and advancing clinically relevant consensus. Our literature selection approach includes the
primary databases used (PubMed, EMBASE) and keywords employed (MAFLD, MASLD, MetALD, dual
etiology).