Page 109 - Read Online
P. 109
Chen et al. Microbiome Res Rep 2025;4:6 https://dx.doi.org/10.20517/mrr.2024.38 Page 13 of 14
Ethical approval and consent to participate
The animal study was approved by the Jiangnan University Experimental Animal Management and Animal
Welfare Ethics Committee (JN. No20230415c1000801[117]).
Consent for publication
Not applicable.
Copyright
© The Author(s) 2024.
REFERENCES
1. Civeira F, Arca M, Cenarro A, Hegele RA. A mechanism-based operational definition and classification of hypercholesterolemia. J
Clin Lipidol 2022;16:813-21. DOI PubMed
2. Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from
genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur
Heart J 2017;38:2459-72. DOI PubMed PMC
3. Wang G, Huang W, Xia Y, Xiong Z, Ai L. Cholesterol-lowering potentials of Lactobacillus strain overexpression of bile salt hydrolase
on high cholesterol diet-induced hypercholesterolemic mice. Food Funct 2019;10:1684-95. DOI PubMed
4. Wang Y, Ai Z, Xing X, et al. The ameliorative effect of probiotics on diet-induced lipid metabolism disorders: a review. Crit Rev Food
Sci Nutr 2024;64:3556-72. DOI PubMed
5. Jones ML, Tomaro-Duchesneau C, Martoni CJ, Prakash S. Cholesterol lowering with bile salt hydrolase-active probiotic bacteria,
mechanism of action, clinical evidence, and future direction for heart health applications. Expert Opin Biol Ther 2013;13:631-42. DOI
PubMed
6. Schneider KM, Albers S, Trautwein C. Role of bile acids in the gut-liver axis. J Hepatol 2018;68:1083-5. DOI PubMed
7. Pushpass RG, Alzoufairi S, Jackson KG, Lovegrove JA. Circulating bile acids as a link between the gut microbiota and cardiovascular
health: impact of prebiotics, probiotics and polyphenol-rich foods. Nutr Res Rev 2022;35:161-80. DOI PubMed
8. Stellaard F, Lütjohann D. Dynamics of the enterohepatic circulation of bile acids in healthy humans. Am J Physiol Gastrointest Liver
Physiol 2021;321:G55-66. DOI PubMed
9. Joyce SA, MacSharry J, Casey PG, et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the
gut. Proc Natl Acad Sci U S A 2014;111:7421-6. DOI PubMed PMC
10. Li F, Jiang C, Krausz KW, et al. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased
obesity. Nat Commun 2013;4:2384. DOI PubMed PMC
11. Kliewer SA, Mangelsdorf DJ. Bile acids as hormones: the FXR-FGF15/19 pathway. Dig Dis 2015;33:327-31. DOI PubMed PMC
12. Chen K, Zhou X, Zhao J, et al. Comparative genomics of Lactobacillus johnsonii reveals extensive intraspecific genetic variation.
Food Biosci 2023;56:103190. DOI
13. Foley MH, Walker ME, Stewart AK, et al. Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth
in the murine gut. Nat Microbiol 2023;8:611-28. DOI PubMed PMC
14. Wang Q, He Y, Li X, et al. Lactobacillus reuteri CCFM8631 alleviates hypercholesterolaemia caused by the paigen atherogenic diet
by regulating the gut microbiota. Nutrients 2022;14:1272. DOI PubMed PMC
15. Dang D, Li B, Ding M, et al. Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid
metabolism and gut microbiota dysbiosis. Food Sci Human Well 2024;13:1589-601. DOI
16. Ding M, Li B, Chen H, et al. Bifidobacterium longum subsp. infantis regulates Th1/Th2 balance through the JAK-STAT pathway in
growing mice. Microbiome Res Rep 2024;3:16. DOI PubMed PMC
17. Chen X, Chen Y, Stanton C, et al. Dose-response efficacy and mechanisms of Orally administered Bifidobacterium breve CCFM683
on IMQ-induced psoriasis in mice. Nutrients 2023;15:1952. DOI PubMed PMC
18. Dang D, Liu X, Chen H, Zhao J, Chen W, Yang B. In silico, in vitro and in vivo safety assessment of three Limosilactobacillus
mucosae strains for probiotic candidates. Food Biosci 2024;57:103462. DOI
19. Huang F, Zheng X, Ma X, et al. Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and
bile acid metabolism. Nat Commun 2019;10:4971. DOI PubMed PMC
20. du Toit M, Franz CM, Dicks LM, et al. Characterisation and selection of probiotic lactobacilli for a preliminary minipig feeding trial
and their effect on serum cholesterol levels, faeces pH and faeces moisture content. Int J Food Microbiol 1998;40:93-104. DOI
PubMed
21. Yoon H, Lee Y, Park H, Kang HJ, Ji Y, Holzapfel WH. Lactobacillus johnsonii BFE6154 ameliorates diet-induced
hypercholesterolemia. Probiotics Antimicrob Proteins 2023;15:451-9. DOI PubMed
22. Teixeira LD, Torrez Lamberti MF, DeBose-Scarlett E, et al. Lactobacillus johnsonii N6.2 and blueberry phytophenols affect lipidome
and gut microbiota composition of rats under high-fat diet. Front Nutr 2021;8:757256. DOI PubMed PMC
23. Xu J, Zhou Y, Cheng S, et al. Lactobacillus johnsonii attenuates liver steatosis and bile acid dysregulation in parenteral nutrition-fed

