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Jiang et al. Microbiome Res Rep 2024;3:47 Microbiome Research
DOI: 10.20517/mrr.2024.12
Reports

Review Open Access

The biofunction of Akkermansia muciniphila in
intestinal-related diseases

1,#
1
5
2,#
3
4
Ping Jiang , Siqi Ji , Dan Su , Yu Zhao , Viriania Berta Esperanca Goncalves , Guifang Xu , Mingming
Zhang 1,2
1
Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University,
Nanjing 210008, Jiangsu, China.
2
Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive
Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong
University, Shanghai 200001, China.
3
FUJIFILM Diosynth Biotechnologies, Watertown, MA 02472, USA.
4
University of Chicago, Pritzker School of Molecular Engineering, Chicago, IL 60637, USA.
5
Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 211166,
Jiangsu, China.
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Authors contributed equally.
Correspondence to: Prof. Guifang Xu, Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of
Medical School, Nanjing University, No.321 Zhongshan Road, Nanjing 210008, Jiangsu, China. E-mail: 13852293376@163.com;
Prof. Mingming Zhang, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key
Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine,
Shanghai Jiao Tong University. No.145 Middle Shandong Road, Shanghai 200001, China. E-mail: doczmm@sjtu.edu.cn
How to cite this article: Jiang P, Ji S, Su D, Zhao Y, Goncalves VBE, Xu G, Zhang M. The biofunction of Akkermansia muciniphila in
intestinal-related diseases. Microbiome Res Rep 2024;3:47. https://dx.doi.org/10.20517/mrr.2024.12
Received: 4 Feb 2024 First Decision: 17 Apr 2024 Revised: 26 Aug 2024 Accepted: 28 Aug 2024 Published: 5 Sep 2024
Academic Editors: Anneleen Segers, Marco Ventura Copy Editor: Pei-Yun Wang Production Editor: Pei-Yun Wang

Abstract
Intestinal homeostasis is essential for maintaining human health, and its dysfunction is related to the onset and
progression of various diseases, including immune and metabolic disorders, and even tumorigenesis. Intestinal
microbiota plays a critical role in intestinal homeostasis, with Akkermansia muciniphila (A. muciniphila) emerging as
a key commensal bacterium utilizing mucin as its sole carbon and nitrogen source. A. muciniphila has been
recognized in both experimental and clinical studies for its beneficial role in managing intestinal inflammation,
tumors, functional gastrointestinal disorders, and secondary conditions such as liver and metabolic diseases. This
review provides a comprehensive overview of the research history and current understanding of A. muciniphila, its
association with various intestinal-related diseases, and the potential mechanisms behind its effects. This paper
also explores the possibilities of leveraging the probiotic enzyme such as the active ingredients of A. muciniphila for

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
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