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Page 8 of 11                    Xu et al. Microbiome Res Rep 2024;3:13  https://dx.doi.org/10.20517/mrr.2023.68

               This inevitably erases species-specific and inter-individual variations in human aging; thus, how to transfer
                                                                                                   [83]
               the findings to humans remains to be investigated. Inserting primate models (e.g., rhesus monkey)  as an
               intermediate transition may work. Certainly, the microbiota system is already highly sophisticated, and even
               more so with human experiments. Human anti-aging studies must be optimized with updated statistical
               tools and multi-omics analysis to obtain more reference data.


               DECLARATIONS
               Authors’ contributions
               Literature searching and manuscript writing: Xu X
               Article revisions: Xu T, Chen T
               Theme formulation and procedure supervision: Xu X, Xu T, Wei J, Chen T
               All authors have checked and agreed to the submitted version.

               Availability of data and materials
               Not applicable.


               Financial support and sponsorship
               None.

               Conflicts of interest
               All authors declared that there are no conflicts of interest.


               Ethical approval and consent to participate
               Not applicable.


               Consent for publication
               Not applicable.


               Copyright
               © The Author(s) 2024.


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