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Komzak et al. Mini-invasive Surg 2021;5:13 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2020.103

Review Open Access

Minimally invasive glaucoma surgery - current and
emerging techniques to reduce intraocular pressure

and medications

Krishna Komzak , Philip Rothschild 1,2,3 , Joobin Hooshmand , Penny Allen , Tze’Yo Toh 6
2,5
1
4
1 Launceston Clinical School, College of Health and Medicine, University of Tasmania, Tasmania, Launceston 7250, Australia.
2 Tasmanian Eye Institute, Tasmania, Launceston 7250, Australia.
3 Alfred Health, Victoria, Melbourne 3000, Australia.
4 Sydney Eye Hospital, New South Wales, Sydney 2000, Australia.
5 Rural Clinical School, College of Health and Medicine, University of Tasmania, Tasmania, Burnie 7320, Australia.
6 Launceston Eye Doctors, Tasmania, Launceston 7250, Australia.

Correspondence to: Mr. Krishna Komzak, Launceston Clinical School, College of Health and Medicine, University of Tasmania, 41
Charles Street, Tasmania, Launceston 7250, Australia. Email: komzakk@utas.edu.au

How to cite this article: Komzak K, Rothschild P, Hooshmand J, Allen P, Toh T. Minimally invasive glaucoma surgery - current and
emerging techniques to reduce intraocular pressure and medications. Mini-invasive Surg 2021;5:13.
http://dx.doi.org/10.20517/2574-1225.2020.103

Received: 10 Nov 2020 First Decision: 5 Jan 2021 Revised: 24 Jan 2021 Accepted: 22 Feb 2021 Published: 12 Mar 2021

Academic Editors: Kazuyuki Hirooka, Giulio Belli Copy Editor: Xi-Jun Chen Production Editor: Xi-Jun Chen

Abstract
Minimally invasive glaucoma surgery (MIGS) has become increasingly popular as a step in the management
pathway of open angle glaucoma. Due to the relative novelty of these devices, there remains some paucity of
evidence relating to their long-term efficacy and safety, and this can make comparison between these techniques
somewhat complex. This review article aims to guide clinical decision making by providing the latest evidence
on the comparative efficacy of current iterations of minimally invasive glaucoma surgery. A literature review
was conducted to identify the most significant recent evidence to support the safety and efficacy of the various
forms of minimally invasive glaucoma surgery. Included studies provided efficacy and safety data on a variety of
minimally invasive glaucoma surgery methods. The PubMed database was searched and a total of 484 studies,
published between 2015 and 2020 were identified, of which 27 were included. The studies indicate that most
available forms of minimally invasive glaucoma surgery show statistically significant efficacy in terms of intra-
ocular pressure reduction and improvement in medication burden, while maintaining an acceptable safety profile.

Keywords: Minimally invasive glaucoma surgery, open angle glaucoma, trabecular microbypass, ab-interno
canaloplasty, trabeculectomy, suprachoroidal, subconjunctival

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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