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Galvez et al. Mini-invasive Surg 2020;4:86 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2020.86

Review Open Access

. stereotactic
Sublobar minimally invasive surgery vs
ablative radiotherapy for early stage non-small cell

lung cancer

Carlos Galvez , Sergio Bolufer , Juan-Manuel Corcoles , Francisco Lirio , Julio Sesma , Juan Jose Mafe ,
1
1
1
1
2
1
Jorge Cerezal 1
1 Thoracic Surgery Department, Hospital General Universitario Alicante, Alicante 03010, Spain.
2 Thoracic Surgery Department, Hospital Vinalopo Elche, Elche, Alicante 03293, Spain.
Correspondence to: Dr. Carlos Galvez, Thoracic Surgery Department, Hospital General Universitario Alicante, Alicante 03010,
Spain. E-mail: carlos.galvez.cto@gmail.com
How to cite this article: Galvez C, Bolufer S, Corcoles JM, Lirio F, Sesma J, Mafe JJ, Cerezal J. Sublobar minimally invasive surgery
vs. stereotactic ablative radiotherapy for early stage non-small cell lung cancer. Mini-invasive Surg 2020;4:86.
http://dx.doi.org/10.20517/2574-1225.2020.86
Received: 26 Aug 2020 First Decision: 16 Oct 2020 Revised: 11 Nov 2020 Accepted: 18 Nov 2020 Published: 5 Dec 2020

Academic Editor: Marcelo F. Jimenez Copy Editor: Cai-Hong Wang Production Editor: Jing Yu

Abstract
Although lobectomy has been traditionally considered the standard treatment for early stage non-small cell lung
cancer (NSCLC), lung-sparing resections usually called “sublobar resections” have exponentially increased in their
use in the age of minimally-invasive surgery. Sublobar resection, especially anatomical segmentectomy, has shown
comparable oncological outcomes in tumors less than 2 cm in diameter without nodal involvement and distant
metastasis. On the other hand, more advanced radiation techniques such as stereotactic ablative radiotherapy, have
shown excellent local control rates in stage I NSCLC, with low rates of post-treatment complications, so not only
is its role growing in inoperable patients, but also in standard-risk stage I patients. There is a need for multicenter
randomized trials addressing specifically this issue. This review aims to collect comparative data about the
outcomes of both treatment strategies in early stage NSCLC.

Keywords: Thoracic surgery, video-assisted, stereotactic radiation therapy, lung neoplasms

INTRODUCTION
Lung cancer is still the leading cause of death by cancer with 1.8 million deaths in 2018 . Stage I non-
[1]
small cell lung cancer (NSCLC) shows a 5-year overall survival (OS) ranging from 68% to 92% in clinical

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
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