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Page 4 of 8                                            Ishida et al. Mini-invasive Surg 2018;2:31  I  http://dx.doi.org/10.20517/2574-1225.2018.53


               Table 1. Retrospective studies comparing reduced port laparoscopic surgery and conventional multiport laparoscopic surgery
               (CMLS) for colorectal cancer (CRC)
                                                  Total patients included
               Author        Publication year  Reference             Accrual  Difference seen in RPS
                                                     (RPS vs. CMLS)
               Kang et al.       2018       31         73 vs. 111   2011-2017  Operation time     Shorter
                                                                               Gas passage time   Longer
               Song et al.       2016       32         32 vs. 217*  2011-2013  Operation time     Shorter
                                                                               Blood loss         Less
                                                                               Gas passage time   Shorter
                                                                               Pain               Less
               Liu et al.        2017       27         48 vs. 48**  2011-2014  3Y DFS             N.S.
                                                                               3Y OS              N.S.
                                                                               Operation time     Shorter
                                                                               Total incision length  Shorter
                                                                               Time to liquid diet  Shorter
                                                                               Time to ambulation  Shorter
                                                                               Discharge          Less
                                                                               Pain               Less
                                                                               Postoperative CRP and   Lower
                                                                               IL-6 levels
                                                                               Cosmesis           Better
               Kawamata et al.   2014       33         20 vs. 20    2010-2012  Operation time     N.S.
                                                                               Postoperative neutrophil   Lower
                                                                               counts
                                                                               Postoperative body   Lower
                                                                               temparature

               RPS: Reduced-port laparoscopic surgery

               ambulation [27,31] . In addition, RPS leads to less postoperative pain and better cosmetic results than does
               CMLS because of the shorter total incision length [27,31] . Therefore, patients who undergo RPS have better
               postoperative outcomes. However, the estimated blood loss, morbidity rate, conversion rate, and number
               of harvested lymph nodes were comparable, suggesting that RPS is a feasible and safe procedure in the
               early postoperative stage [27,30] . Furthermore, the postoperative neutrophil count, C-reactive protein level,
               interleukin-6 level, and body temperature were significantly lower after RPS compared with CMLS [27,32] ,
               which may accelerate recovery. Another advantage of RPS may be its cost effectiveness. The instrument
               cost for RPS may be lower due to the reduced number of trocars required; however, previous studies
               have not evaluated this factor. A shortened hospital stay and decreased analgesic use may also reduce the
               cost [34,35] .


               A MIAP can be placed at the ileostomy site and the excised specimen can be brought out during a reduced
               port laparoscopic low anterior resection with diverting ileostomy. Furthermore, a drainage tube can be
                                         [36]
               placed via the additional port . The use of MIAP as the ileostomy site represents a minimally invasive
               approach that results in a scarless procedure.

               Superiority of RPS over SILS
                                                                                [37]
               RPS for CRC may have several advantages over CMLS. Since Burcher et al.  performed the first SILS for
               colorectal diseases, it has become widely used because of technical advancements. However, SILS has a risk
               of collisions between instruments and is limited by use of triangular tissue traction [21,24,38] ; consequently,
                                               [36]
               SILS is used infrequently worldwide . In contrast, the additional port created during RPS reduces the
               risk of collision between surgical instruments and the laparoscope, as well as shortening the operation
                                     [27]
               time compared with SILS . Therefore, RPS involves fewer technical difficulties than does SILS. Moreover,
               RPS has other advantages over SILS, such as the convenience of an intracorporeal suture and stable drain
               placement via the additional port.
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