Page 72 - Read Online
P. 72
Shad. J Transl Genet Genom 2023;7:141-65 https://dx.doi.org/10.20517/jtgg.2023.11 Page 161
57. Piatkov I, Caetano D, Assur Y, et al. CYP2C19*17 protects against metabolic complications of clozapine treatment. World J Biol
Psychiatry 2017;18:521-7. DOI
58. Lee ST, Ryu S, Kim SR, et al. Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting
studies and identification of a new candidate gene, ABCB1, for treatment response. J Clin Psychopharmacol 2012;32:441-8. DOI
59. Shaikh S, Collier DA, Sham PC, et al. Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and
schizophrenia. Hum Genet 1996;97:714-9. DOI
60. Scharfetter J, Chaudhry HR, Hornik K, et al. Dopamine D3 receptor gene polymorphism and response to clozapine in schizophrenic
Pakistani patients. Eur Neuropsychopharmacol 1999;10:17-20. DOI PubMed
61. Hwang R, Zai C, Tiwari A, et al. Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory
analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J 2010;10:200-18. DOI PubMed
62. Huang E, Maciukiewicz M, Zai CC, et al. Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk
variant with clozapine response. Pharmacogenomics 2016;17:103-9. DOI
63. Hwang R, Shinkai T, Deluca V, et al. Dopamine D2 receptor gene variants and quantitative measures of positive and negative
symptom response following clozapine treatment. Eur Neuropsychopharmacol 2006;16:248-59. DOI
64. Hwang R, Shinkai T, De Luca V, et al. Association study of 12 polymorphisms spanning the dopamine D receptor gene and
2
clozapine treatment response in two treatment refractory/intolerant populations. Psychopharmacology 2005;181:179-87. DOI
65. Malhotra A. Allelic variation in the promoter region of the dopamine D-2 receptor gene and clozapine response. In: Schizophrenia
research. Amsterdam, Netherlands: Elsevier Science B.V.; 1999.
66. Hwang R, Tiwari AK, Zai CC, et al. Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia:
replication and exploration. Prog Neuropsychopharmacol Biol Psychiatry 2012;37:62-75. DOI
67. Zhao AL, Zhao JP, Zhang YH, Tang BS, Liu ZN, Cheng JD. [Distribution of genotype and allele frequencies of dopamine D4
receptor gene 48 bp variable number tandem repeat polymorphism in Chinese Han population in Hunan]. Zhonghua Yi Xue Yi
Chuan Xue Za Zhi 2005;22:470-2. PubMed
68. Hwang R, Shinkai T, De Luca V, et al. Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment
response. J Psychopharmacol 2007;21:718-27. DOI PubMed
69. Potkin SG, Basile VS, Jin Y, et al. D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine. Mol
Psychiatry 2003;8:109-13. DOI
70. Woodward ND, Jayathilake K, Meltzer HY. COMT val108/158met genotype, cognitive function, and cognitive improvement with
clozapine in schizophrenia. Schizophr Res 2007;90:86-96. DOI PubMed
71. Xu M, Xing Q, Li S, et al. Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and
clozapine and on extrapyramidal syndrome in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:1026-32. DOI
72. Arranz MJ, Collier DA, Munro J, et al. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to
clozapine. Neurosci Lett 1996;217:177-8. PubMed
73. Arranz MJ, Munro J, Owen MJ, et al. Evidence for association between polymorphisms in the promoter and coding regions of the 5-
HT2A receptor gene and response to clozapine. Mol Psychiatry 1998;3:61-6. DOI PubMed
74. Masellis M, Basile V, Meltzer HY, et al. Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia
patients. Neuropsychopharmacology 1998;19:123-32. DOI
75. Arranz M, Collier D, Sodhi M, et al. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet
1995;346:281-2. DOI
76. Souza RP, de Luca V, Meltzer HY, Lieberman JA, Kennedy JL. Influence of serotonin 3A and 3B receptor genes on clozapine
treatment response in schizophrenia. Pharmacogenet Genomics 2010;20:274-6. DOI PubMed
77. Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M, Jacob KS. Outcome definitions and clinical predictors influence
pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia.
Psychopharmacology 2012;224:441-9. DOI PubMed
78. Kohlrausch FB, Salatino-Oliveira A, Gama CS, Lobato MI, Belmonte-de-Abreu P, Hutz MH. Influence of serotonin transporter gene
polymorphisms on clozapine response in Brazilian schizophrenics. J Psychiatr Res 2010;44:1158-62. DOI PubMed
79. Yu YW, Tsai SJ, Lin CH, Hsu CP, Yang KH, Hong CJ. Serotonin-6 receptor variant (C267T) and clinical response to clozapine.
Neuroreport 1999;10:1231-3. DOI PubMed
80. Sodhi MS, Arranz MJ, Curtis D, et al. Association between clozapine response and allelic variation in the 5-HT2C receptor gene.
Neuroreport 1995;7:169-72. PubMed
81. Arranz MJ, Munro J, Birkett J, et al. Pharmacogenetic prediction of clozapine response. Lancet 2000;355:1615-6. DOI
82. Hwang R, Souza RP, Tiwari AK, et al. Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene
variants and clozapine response. Pharmacogenomics 2011;12:277-91. DOI
83. Bosia M, Lorenzi C, Pirovano A, et al. COMT Val158Met and 5-HT1A-R-1019 C/G polymorphisms: effects on the negative
symptom response to clozapine. Pharmacogenomics 2015;16:35-44. DOI
84. Rajagopal VM, Rajkumar AP, Jacob KS, Jacob M. Gene-gene interaction between DRD4 and COMT modulates clinical response to
clozapine in treatment-resistant schizophrenia. Pharmacogenet Genomics 2018;28:31-5. DOI PubMed
85. Xu M, Lin Z. Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases
and 1753 controls. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1255-60. DOI PubMed PMC

