Page 2 - Read Online

Topic: Translational
Prof. Bernhard H.F.
Weber
Prof. Weber is the full
Professor, head of Institute of
Human Genetics, University
of Regensburg Germany. The
focus of the research group of
Bernhard Weber is on disease
mechanisms in hereditary as
well as multifactorial retinal
degenerations. Prof. Weber
mainly focuses on Genetics,
Macular degeneration,
Stargardt disease, Gene and
Exon. His work on Genetics
is being expanded to include
thematically relevant topics
such as Phenylbutyrate.
His studies in Macular
degeneration integrate themes
in fields like Eye disease,
Genetic risk, Fundus and Age
related.
Research into Retinal
Diseases
The translation of retinal research from bench to
bedside is of utmost importance because of the
urgent need to provide innovative treatments for
individuals affected by the devastating blinding
disorders. One promising approach is to tailor
treatment options to the causal genetic insult
and mode of inheritance. For example, while
autosomal recessive inheritance can benefit
from gene augmentation, a dominant negative
disease may be better targeted by disrupting
the disease-causing allele. Further, complex
diseases which develop at the interface between
genetic predisposition and environmental
risk factors generally lack a straightforward
therapeutic approach. The Special Issue on
“Translational Research into Retinal Diseases”
addresses a number of topics focused on the
manifold opportunities and unique challenges
in the field of neuro-retinal disease:
1.Methodological advances in iPSC-derived
2D/3D retinal cells;
2.Methodological advances in animal models
of retinal disease;
3.Development of therapeutic concepts;
4.Demonstration of potential treatment options.