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Topic: Genetics and

Epigenetics of Prostate

Cancer: from Etiology to

Treatment

Prostate cancer is the second leading cause of death in
men and its development and progression is dependent
Prof. Sanjay Gupta on androgens/androgen receptor. The etiology of prostate
cancer still remains elusive with genetic, epigenetic,
Prof. Sanjay Gupta is a Professor & Research environmental, and lifestyle factors associated with
Director holding the Carter Kissell Endowed Chair increased disease risk. The post-genome era research
in Urologic Oncology in the Department of Urology
at Case Western Reserve University, USA and on prostate cancer has identified genetic variations
The Urology Institute at the University Hospitals associated with the disease including potential germline
Cleveland Medical Center. He also has secondary polymorphisms and allelic imbalances linked with
appointments in the Departments of Nutrition prostate cancer susceptibility. Epigenetic mechanisms
and Division of General Medical Sciences at Case such as DNA hyper- or hypo- methylation, histone
Comprehensive Cancer Center. Additionally, modifications and involvement of non-coding RNAs
Prof. Gupta has a joint appointment as Research in gene transcription permit unchanging inheritance of
Scientist at the Louis Stokes VA Medical Center, phenotypes without changes in the DNA sequence. Such
Cleveland, Ohio. He joined Case Western Reserve epigenetic modifications are developed as biomarkers
University’s School of Medicine as a faculty member
in 2022. Prof. Gupta’s research encompasses basic, for early detection, stratification and risk assessment of
translational and clinical areas of focus. In the prostate cancer. In addition, current treatment options
realm of basic research, he aims to understand the and novel drug combinations have strong potential for
risk factors and mechanisms of prostatic, breast, durable therapeutic responses and eventual cures for
kidney and bladder diseases and develop appropriate advanced disease. Improved disease management will
biomarkers for early detection and prognosis. His also benefit from artificial intelligence-based decision
translational research endeavors involve identifying support for disease prognosis and appropriate standard
novel targets to assess the efficacy of various of care to minimize overtreatment of localized disease,
synthetic and natural small molecules, with the
goal of developing them as chemopreventatives/ and new standards of care augmented by next-generation
therapeutics. Furthermore, his clinical research adaptive clinical trials. The aim of this Special Issue on
interests lie in translating bench research into prostate cancer is to provide an updated knowledge on
practical applications in clinical settings. Prof. the epidemiology, etiology, diagnosis and treatment of
Gupta has authored over 150 publications, including prostate cancer.
book chapters,research articles, and reviews. He has
also delivered presentations at numerous national
and international cancer prevention symposiums,
seminars, and meetings. He has contributed to
various study sections at the National Cancer
Institute (NCI) and Department of Defense (DOD),
and other global councils.