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Page 206 Lu et al. J Transl Genet Genom 2020;4:203-9 I http://dx.doi.org/10.20517/jtgg.2020.33

Multiple confirmed alleles

Systems analysis
(Protein-protein interaction)

Target evaluative models

Convergent structural and functional phenotypes

Target development

Figure 1. Therapeutic and drug design development

high suicide risk have begun to emerge for determining disease progression or multi-factorial etiological
identification [18-26] .

The genetic changes in psychiatric diseases are enormous, such as UNC13A, NFASC, PTPRG, ERBB2,
GR1N2A, HTR2A, DLG, ACTN, MYH9 and many others [32,33] . So far, at least 400 human genes are involved
in neuropsychiatric disorders and much more scientific research is needed.

Toxicity of antidepressants
Antidepresssants have been implicated as inducers of human suicide and has been reported with
mechanistic investigation. We have previously studied and discussed drug toxicity from a genetics
perspective. Our proposition is that some patients with genetic deficiencies may develop an over-reaction
[26]
to antidepressants and induce human suicide . This can explain the clinical suicides that are evidenced
in only a small number of patients receiving antidepressants. Most patients are otherwise safe with
antidepressant medication.

Neuropathy
To provide a high-quality platform for human suicide study, neuropathic processes may be understood [34-36] .
These complex processes have been explored over the past two decades due to technical updating (genetic
or morphology). Many specific neural structural or functional elements or areas have been studied. This
interesting topic may be a fruitful discipline in the upcoming decades worldwide.

Therapeutic study and drug development
Therapeutic studies for neuropsychiatric diseases have increased greatly. Possible therapeutic and drug
design pathways are given in Figure 1. In this stage, antidepressants (selective serotonin reuptake inhibitor,
SSRI) are widely utilized in clinical trials and show therapeutic outcomes and benefits clinically .
[30]

Apart from drug treatment, other types of therapies, such as light therapy (physical treatment) are also
[37]
useful for mood disorders or suicidal patients . In Scandinavia, there is a seasonal shift in human suicides
or rates of mood disorders every year. Light therapy could help these special types of patients in the winter
of each country in Scandinavia.