Page 5 - Read Online
P. 5
www.jtggjournal.com
Special Issue
Genetics and Genomics of Cancer
Guest Editor: Special Issue Introduction
David N. Cooper, PhD Tumorigenesis is a multistep process that begins with the
Professor of Human transformation of a single cell which acquires one or more of the
Molecular Genetics, Institute ''hallmarks of cancer''. Cells acquire these characteristics through
of Medical Genetics, School numerous somatic mutations caused by errors of DNA replication, the
of Medicine, Cardiff action of exogenous mutagens or endogenous DNA damage, leading
University, UK to the activation of oncogenes and the inactivation of tumour
Email: suppressors. Different tumours differ with respect to their mutational
CooperDN@cardiff.ac.uk spectra and these patterns of mutation are often characteristic of the
tumour in question. Genetic susceptibility to cancer is also conferred by
inherited variants of cancer predisposition genes. As whole
exome/genome sequencing becomes commonplace in a clinical
genetics/personalised genomics setting, we are gradually developing
an understanding of the role of both inherited and acquired variants in
tumorigenesis. We plan to publish reviews of the molecular genetics of
human cancers which we hope will allow the reader to compare and
contrast some of the 100+ different human cancers in terms of their
underlying mutational spectra.
Benets
Rigorous mechanism in peer review: one manuscript must be
reviewed by at least two relevant experts. We will endeavour to
ensure high standards for the review process and subsequent
publication by a team of efcient and professional reviewers and
scientic editors.
No publication fee: there would be absolutely no charge for
publication.
Rapid publication: we will do our best to ensure that accepted
papers will be published rapidly with a high quality.
Open Access: As an author you will retain the copyright to your work.
By licensing your work under the Creative Commons Attribution
License, articles can be re-used and re-distributed without restriction,
as long as the original work is correctly cited.
Wide promotions: Published articles will be promoted at academic
conferences, through social networks for scientists and relevant
indexing services.
245 E Main Street ste122, Alhambra, CA 91801, USA；
www.jtggjournal.com/
Tel：+1 323 9987086；E-mail：editorial@jtggjournal.com journal/special_detail/150
