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Page 4 of 7 Komiya et al. J Cancer Metastasis Treat 2020;6:4 I http://dx.doi.org/10.20517/2394-4722.2019.41

Figure 1. A trend of brain metastasis as exclusion criteria in extensive-stage small cell lung cancer. Each bar indicates percentage of each
group regarding exclusion of brain metastasis

Table 2. Characteristics of studies in extensive-stage small cell lung cancer
Characteristics Variables Excluded all BM (%) Others (%) Total P
Total 69 (14) 421 (86) 490
Impact factor < 10 43 (14) 271 (86) 314 0.875
≥ 10 26 (15) 150 (85) 176
Publication year 1970-1999 38 (20) 155 (80) 193 < 0.0001
2000-2018 30 (10) 267 (90) 297
Region US included 27 (14) 169 (86) 196 0.957
Non-US 41 (14) 253 (86) 294
Study phase III 11 (11) 88 (89) 99 0.373
Others 57 (15) 334 (85) 391
Study line 1st +/- M 53 (16) 283 (84) 336
M 3 (19) 13 (81) 16
1st and 2nd 3 (14) 18 (86) 21
2nd 8 (7) 101 (93) 109
Unknown 1 (13) 7 (87) 8
1st or M 59 (16) 314 (84) 373 0.027
Others 9 (8) 108 (92) 117
Randomization Yes 17 (10) 149 (90) 166 0.096
No 51 (16) 273 (84) 324
Sample size < 100 51 (14) 308 (86) 359 0.727
≥ 100 17 (13) 114 (87) 131
ECOG/WHO PS 0-1 6 (10) 52 (90) 58 0.407
Others 62 (15) 370 (85) 432
Age Upper Limit Yes 19 (13) 125 (87) 144 0.778
No 49 (14) 297 (86) 346
Anti-angiogenesis Yes 3 (16) 16 (84) 19 0.763
No 63 (13) 408 (87) 471
BM: brain metastasis; M: maintenance; ECOG: Eastern Cooperative Oncology Group; WHO: World Health Organization; PS: performance
status