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Page 6 of 17 Li et al. J Cancer Metastasis Treat 2020;6:14 I http://dx.doi.org/10.20517/2394-4722.2020.27
A
B
Figure 2. Oncogenic fusions lead to ligand-independent, constitutive activation of kinases and their downstream signal pathways. A:
Fusions with N-terminal partners, represented by tropomyosin receptor kinase (TRK) fusions; B: fusions with C-terminal partners,
represented by fibroblast growth factor receptor fusions. AKT: protein kinase B
of nerve growth factors including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
[47]
and neurotrophins . Neurotrophin binding to TRK receptors results in receptor autophosphorylation
