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Although several questions are still open, soon further improvements might help to generate
microenvironments that also mimic the bacteria and virus migratory potential.
CONCLUsION
Overall this review highlights the importance of the in vitro 3D modeling research field for the study of
microbial induced epithelial carcinogenesis. Yet, further improvements are still needed to reach the level of
complexity of the real tissue. These models will hopefully help to better understand the respective roles of
virus and bacteria in HR-HPV-related cancers.
DeCLaRaTIONs
Acknowledgments
Authors thank Michelle Schoeman for the linguistic revision.
Authors’ contributions
Wrote part of the paper and prepared Table 1: Squarzanti DF
Wrote part of the paper and prepared Figure 1: Sorrentino R
Designed the review article and wrote part of the paper: Azzimonti B
Availability of data and materials
Not applicable.
Financial support and sponsorship
DFS was partially supported by BioLab Srl/Probiotical SpA.
Conflicts of interest
All authors declared that there are no conflicts of interest.
Ethical approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Copyright
© The Author(s) 2019.
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