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REFERENCES
1. Hawkes N. Cancer survival data emphasise importance of early diagnosis. BMJ 2019;364:l408.
2. Hosseini H, Obradovic MMS, Hoffmann M, Harper KL, Sosa MS, et al. Early dissemination seeds metastasis in breast cancer. Nature
2016;540:552-8.
3. Wan L, Pantel K, Kang Y. Tumor metastasis: moving new biological insights into the clinic. Nat Med 2013;19:1450-64.
4. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, et al. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for
hepatoma invasion and metastasis in mice. Hepatology 2018;67:2226-43.
5. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med 2013;19:1423-37.
6. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139:871-90.
7. Massague J, Obenauf AC. Metastatic colonization by circulating tumour cells. Nature 2016;529:298-306.
8. Fischer KR, Durrans A, Lee S, Sheng J, Li F, et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but
contributes to chemoresistance. Nature 2015;527:472-6.
9. Cazet AS, Hui MN, Elsworth BL, Wu SZ, Roden D, et al. Targeting stromal remodeling and cancer stem cell plasticity overcomes
chemoresistance in triple negative breast cancer. Nat Commun 2018;9:2897.
10. Yin Z, Pascual C, Klionsky D. Autophagy: machinery and regulation.Microb Cell 2016;3:588-96.
11. Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol
2011;13:132-41.
12. Parzych KR, Klionsky DJ. An Overview of Autophagy: Morphology, Mechanism, and Regulation. Antioxid Redox Signal
2014;20:460-73.
13. Feng Y, He D, Yao Z, Klionsky DJ. The machinery of macroautophagy 24 The machinery of macroautophagy. Cell Res 2014;24:24-41.
14. Lee YK, Lee JA. Role of the mammalian ATG8/LC3 family in autophagy: Differential and compensatory roles in the spatiotemporal
regulation of autophagy. BMB Rep 2016;49:424-30.
15. Nazio F, Bordi M, Cianfanelli V, Locatelli F, Cecconi F. Autophagy and cancer stem cells: molecular mechanisms and therapeutic
applications. Cell Death Differ 2019;26:690-702.
16. Gugnoni M, Sancisi V, Manzotti G, Gandolfi G, Ciarrocchi A. Autophagy and epithelial-mesenchymal transition: an intricate
interplay in cancer. Cell Death Dis 2016;7:e2520.
17. Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, et al. The autophagy-associated factors DRAM1 and p62 regulate
cell migration and invasion in glioblastoma stem cells. Oncogene 2013;32:699-712.
18. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-26.
19. Meredith JE, Fazeli B, Schwartz MA, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993;4:953-61.
20. Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival.
Mol Biol Cell 2008;19:797-806.
21. Kenific CM, Thorburn A, Debnath J. Autophagy and metastasis: Another double-edged sword. Curr Opin Cell Biol 2010;22:241-5.
22. Peng YF, Shi YH, Ding ZB, Ke AW, Gu CY, et al. Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via
impairing anoikis resistance and colonization of HCC cells. Autophagy 2013;9:2056-68.
23. Mowers EE, Sharifi MN, Macleod KF. Autophagy in cancer metastasis. Oncogene 2017;36:1619-30.
24. Chen HT, Liu H, Mao MJ, Tan Y, Mo XQ, et al. Crosstalk between autophagy and epithelial-mesenchymal transition and its
application in cancer therapy. Mol Cancer 2019;18:101.
25. Banyard J, Bielenberg DR. The role of EMT and MET in cancer dissemination. Connect Tissue Res 2015;56:403-13.
26. Barnard RA, Regan DP, Hansen RJ, Maycotte P, Thorburn A, et al. Autophagy Inhibition Delays Early but Not Late-Stage Metastatic
Disease. J Pharmacol Exp Ther 2016;358:282-93.
27. Paul P, Chakraborty A, Sarkar D, Langthasa M, Rahman M, et al. Interplay between miRNAs and human diseases. J Cell Physiol
2018;233:2007-18.
28. O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol
(Lausanne) 2018;9:402.
29. Di Leva G, Garofalo M, Croce CM. MicroRNAs in Cancer. Annu Rev Pathol 2014;9:287-314.
30. Wang W, Liu Y, Guo J, He H, Mi X, et al. miR-100 maintains phenotype of tumor-associated macrophages by targeting mTOR to
promote tumor metastasis via Stat5a/IL-1ra pathway in mouse breast cancer. Oncogenesis 2018;7:97.
31. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, et al. TGF-β induces miR-100 and miR-125b but blocks let-7a through
LIN28B controlling PDAC progression. Nature Communications 2018;9:10.
32. Zhang F, Wang J, Chu J, Yang C, Xiao H, et al. MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-
2. Cell Physiol Biochem 2015;37:1442-53.