Page 879 - Read Online

Chien et al. J Cancer Metastasis Treat 2019;5:66 I http://dx.doi.org/10.20517/2394-4722.2019.016 Page 9 of 10

therapeutic resistance in glioblastoma. Biochem Biophys Res Commun 2017;493:14-19
37. Lin CJ, Lee CC, Shih YL, Lin CH, Wang SH, et al. Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy
augments temozolomide-induced apoptosis in glioma cells. PLoS One 2012;7:e38706.
38. Quijano C, Trujillo M, Castro L, Trostchansky A. Interplay between oxidant species and energy metabolism. Redox Biol 2016;8:28-42.
39. Guerra F, Arbini AA, Moro L. Mitochondria and cancer chemoresistance. Biochimica et biophysica acta. Biochim Biophys Acta Bioenerg
2017;1858:686-99.
40. Wang L, Shang Z, Zhou Y, Hu X, Chen Y, et al. Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and
chemoresistance through coordinating cell metabolism, cell cycle, and survival. Cell Death Dis 2018;9:213.
41. Kriel J, Müller-Nedebock K, Maarman G, Mbizana S, Ojuka E, et al. Coordinated autophagy modulation overcomes glioblastoma
chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 2018;8:10348.
42. Vidal SJ, Rodriguez-Bravo V, Galsky M, Cordon-Cardo C, Domingo-Domenech J. Targeting cancer stem cells to suppress acquired
chemotherapy resistance. Oncogene 2014;33:4451-63.
43. Lathia JD, Mack SC, Mulkearns-Hubert EE, Valentim CL, Rich JN. Cancer stem cells in glioblastoma. Genes Dev 2015;29:1203-17.
44. Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, et al. The autophagy-associated factors DRAM1 and p62 regulate cell
migration and invasion in glioblastoma stem cells. Oncogene 2013; 32:699-712.
45. Colella B, Faienza F, Di Bartolomeo S. EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology. Cancers (Basel)
2019;11:E312.
46. Catalano M, D'Alessandro G, Lepore F, Corazzari M, Caldarola S, et al. Autophagy induction impairs migration and invasion by reversing
EMT in glioblastoma cells. Mol Oncol 2015;9:1612-25.
47. Jiang C, Shen F, Du J, Fang X, Li X, et al. Upregulation of CASC2 sensitized glioma to temozolomide cytotoxicity through autophagy
inhibition by sponging miR-193a-5p and regulating mTOR expression. Biomed Pharmacother 2018;97:844-50.
48. Filippi-Chiela EC, Villodre ES, Zamin LL, Lenz G. Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting
effect of resveratrol in glioma cells. PLoS One 2011;6:e20849.
49. Buccarelli M, Marconi M, Pacioni S, De Pascalis I, D'Alessandris QG, et al. Inhibition of autophagy increases susceptibility of glioblastoma
stem cells to temozolomide by igniting ferroptosis. Cell Death Dis 2018;9:841.
50. Wang WJ, Long LM, Yang N, Zhang QQ, Ji WJ, et al. NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of
human glioma stem cells in vitro. Acta Pharmacol Sin 2013;34:681-90.
51. Singer E, Judkins J, Salomonis N, Matlaf L, Soteropoulos P, et al. Reactive oxygen species-mediated therapeutic response and resistance in
glioblastoma. Cell Death Dis 2015;6:e1601.
52. Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity,
Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell 2017;2:840-55.e848.
53. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, et al. A novel response of cancer cells to radiation involves autophagy and
formation of acidic vesicles. Cancer Res 2001;61:439-44.
54. Ito H, Daido S, Kanzawa T, Kondo S, Kondo Y. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant
glioma cells. Int J Oncol 2005;26:1401-10.
55. Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, et al. Inhibition of radiation-induced glioblastoma invasion by genetic and
pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A 2017;114:370-75.
56. Koukourakis MI, Mitrakas AG, Giatromanolaki A. Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma:
evidence and issues to resolve. Brit J Cancer 2016;114:485-96.
57. Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, et al. The induction of autophagy by gamma-radiation contributes to the
radioresistance of glioma stem cells. Int J Cancer 2009;125:717-22.
58. Fu J, Liu ZG, Liu XM, Chen FR, Shi HL, et al. Glioblastoma stem cells resistant to temozolomide-induced autophagy. Chin Med J (Engl)
2009;122:1255-9.
59. Ciechomska IA, Przanowski P, Jackl J, Wojtas B, Kaminska B. BIX01294, an inhibitor of histone methyltransferase, induces autophagy-
dependent differentiation of glioma stem-like cells. Sci Rep 2016;6:38723.
60. Palumbo S, Comincini S. Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma. J Cell Physiol 2013;228:1-8.
61. Jo GH, Bogler O, Chwae YJ, Yoo H, Lee SH, et al. Radiation-induced autophagy contributes to cell death and induces apoptosis partly in
malignant glioma cells. Cancer Res Treat 2015;47:221-41.
62. Mendiburu-Elicabe M, Gil-Ranedo J, Izquierdo M. Efficacy of rapamycin against glioblastoma cancer stem cells. Clin Transl Oncol
2014;16:495-502.
63. Cerniglia GJ, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, et al. Inhibition of autophagy as a strategy to augment
radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Mol Pharmacol
2012;82:1230-40.
64. Gil del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, et al. Inhibition of DNA double-strand break repair by the dual
PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma. Clinical cancer research 2014;20:1235-48.
65. Zhuang W, Li B, Long L, Chen L, Huang Q, et al. Induction of autophagy promotes differentiation of glioma-initiating cells and their
radiosensitivity. Int J Cancer 2011;129:2720-31.
66. Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, et al. A molecular cascade modulates MAP1B and confers resistance to
mTOR inhibition in human glioblastoma. Neuro Oncol 2018;20:764-75.
67. Rosenfeld MR, Ye X, Supko JG, Desideri S, Grossman SA, et al. A phase I/II trial of hydroxychloroquine in conjunction with radiation
therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 2014;10:1359-
68.
68. Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, et al. Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs