Page 215 - Read Online

Page 8 of 9 Saccà et al. J Cancer Metastasis Treat 2019;5:15 I http://dx.doi.org/10.20517/2394-4722.2018.95

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

REFERENCES
1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7-30.
2. Jin X, Mu P. Targeting breast cancer metastasis. Breast Cancer (Auckl) 2015;9:23-34.
3. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011;147:275-92.
4. Wang Y, Zhou BP. Epithelial-mesenchymal transition---a hallmark of breast cancer metastasis. Cancer Hallm 2013;1:38-49.
5. Li X, Pei D, Zheng H. Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell 2014;5:580-91.
6. Unger-Saldaña K. Challenges to the early diagnosis and treatment of breast cancer in developing countries. World J Clin Oncol 2014;5:465-77.
7. Sun L, Fang J. Epigenetic regulation of epithelial-mesenchymal transition. Cell Mol Life Sci 2016;73:4493-515.
8. Hübner MR, Spector DL. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol
2010;75:43-9.
9. Ramadoss S, Chen X, Wang CY. Histone demethylase KDM6B promotes epithelial-mesenchymal transition. J Biol Chem 2012;287:44508-17.
10. Enkhbaatar Z, Terashima M, Oktyabri D, Tange S, Ishimura A, et al. KDM5B histone demethylase controls epithelial-mesenchymal
transition of cancer cells by regulating the expression of the microRNA-200 family. Cell Cycle 2013;12:2100-12.
11. Jiang GM, Wang HS, Zhang F, Zhang KS, Liu ZC, et al. Histone deacetylase inhibitor induction of epithelial-mesenchymal transitions via
up-regulation of Snail facilitates cancer progression. Biochim Biophys Acta 2013;1833:663-71.
12. Ambrosio S, Saccà CD, Majello B. Epigenetic regulation of epithelial to mesenchymal transition by the Lysine-specific demethylase LSD1/
KDM1A. Biochim Biophys Acta Gene Regul Mech 2017;1860:905-10.
13. Ambrosio S, Amente S, Saccà CD, Capasso M, Calogero RA, et al. LSD1 mediates MYCN control of epithelial-mesenchymal transition
through silencing of metastatic suppressor NDRG1 gene. Oncotarget 2017;8:3854-69.
14. Choi HJ, Park JH, Park M, Won HY, Joo HS, et al. UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT
genes in cooperation with LSD1 and HDAC1. EMBO Rep 2015;16:1288-98.
15. Lin T, Ponn A, Hu X, Law BK, Lu J. Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during
epithelial-mesenchymal transition. Oncogene. 2010;29:4896-904.
16. Amente S, Lania L, Majello B. The histone LSD1 demethylase in stemness and cancer transcription programs. Biochim Biophys Acta
2013;1829:981-6.
17. Nagasawa S, Sedukhina AS, Nakagawa Y, Maeda I, Kubota M, et al. LSD1 overexpression is associated with poor prognosis in basal-like
breast cancer, and sensitivity to PARP inhibition. PLoS One 2015;10:e0118002.
18. Lim S, Janzer A, Becker A, Zimmer A, Schüle R, et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast
cancers and a biomarker predicting aggressive biology. Carcinogenesis 2010;31:512-20.
19. Schulte JH, Lim S, Schramm A, Friedrichs N, Koster J, et al. Lysine-specific demethylase 1 is strongly expressed in poorly differentiated
neuroblastoma: implications for therapy. Cancer Res 2009;69:2065-71.
20. Wang Y, Zhang H, Chen Y, Sun Y, Yang F, et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast
cancer. Cell 2009;138:660-72.
21. Luo H, Shenoy AK, Li X, Jin Y, Jin L, et al. MOF acetylates the histone demethylase LSD1 to suppress epithelial-to-mesenchymal
transition. Cell Rep 2016;15:2665-78.
22. Boulding T, McCuaig RD, Tan A, Hardy K, Wu F, et al. LSD1 activation promotes inducible EMT programs and modulates the tumour
microenvironment in breast cancer. Sci Rep 2018;8:73.
23. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell
2004;119:941-53.
24. Forneris F, Binda C, Vanoni MA, Mattevi A, Battaglioli E. Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative
process. FEBS Lett 2005;579:2203-7.
25. Forneris F, Binda C, Battaglioli E, Mattevi A. LSD1: oxidative chemistry for multifaceted functions in chromatin regulation. Trends
Biochem Sci 2008;33:181-9.
26. Lan F, Nottke AC, Shi Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol 2008;20:316-25.
27. Forneris F, Binda C, Vanoni MA, Battaglioli E, Mattevi A. Human histone demethylase LSD1 reads the histone code. J Biol Chem
2005;280:41360-5.
28. Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, et al. p53 is regulated by the lysine demethylase LSD1. Nature 2007;449:105-8.
29. Wang J, Hevi S, Kurash JK, Lei H, Gay F, et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA
methylation. Nat Genet 2009;41:125-9.
30. Kontaki H, Talianidis I. Lysine methylation regulates E2F1-induced cell death. Mol Cell 2010;39:152-60.
31. Cho H-S, Suzuki T, Dohmae N, Hayami S, Unoki M, et al. Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes
cell cycle progression in cancer cells. Cancer Res 2011;71:655-60.