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CONCLUSION
In conclusion, new genetic technologies are improving the detection of micrometastasis in the peritoneum,
although conventional cytology is still the gold standard for PLC. The development of genetic PLC based on
comprehensive genomic analysis could help us to identify patients who should be treated completely with
multimodal therapy in addition to radical surgery, and will be very relevant to all sorts of clinical decision-
making.

DECLARATIONS
Acknowledgments
We would like to thank our colleagues in our laboratory for helpful discussions. We apologize for not being
able to cite all the relevant publications due to space limits.

Authors’ contributions
Designed this review: Yashiro M, Matsuoka T
Wrote and edited the manuscript: Matsuoka T

Financial support and sponsorship
None.

Conflicts of interest
There are no conflicts of interest.

Patient consent
Not applicable.

Ethics approval
Not applicable.

Copyright
© The Author(s) 2018.

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