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inhibitor VS-5584 preferentially targets cancer stem cells. Cancer   cell carcinoma. Curr Treat Options Oncol 2013;14:249-63.
                Res 2015;75:446-55.                           110.  Samimi  M,  Touze  A.  Merkel  cell  carcinoma:  The  first  human
            94.  Eliasz  S, Liang S, Chen  Y, De Marco MA, Machek O, Skucha   cancer shown to be associated with a polyomavirus. Presse Med
                S, Miele L, Bocchetta M. Notch-1 stimulates  survival of lung   2014;43:e405-11.
                adenocarcinoma  cells during hypoxia by activating  the IGF-1R   111.  Feng H, Shuda M, Chang  Y, Moore PS. Clonal  integration
                pathway. Oncogene 2010;29:2488-98.                of a polyomavirus  in human  Merkel cell  carcinoma.  Science
            95.  Sriuranpong  V, Borges MW, Ravi RK, Arnold DR, Nelkin  BD,   2008;319:1096-100.
                Baylin SB, Ball DW. Notch signaling induces cell cycle arrest in   112.  Shuda M,  Feng H,  Kwun  HJ,  Rosen ST, Gjoerup O,  Moore
                small cell lung cancer cells. Cancer Res 2001;61:3200-5.  PS,  Chang  Y.  T  antigen  mutations  are  a  human  tumor-specific
            96.  Zhou M,  Jin WY, Fan ZW, Han RC. Analysis of the expression   signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A
                of  the  Notch3  receptor  protein  in  adult  lung  cancer.  Oncol  Lett   2008;105:16272-7.
                2013;5:499-504.                               113.  Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS. Human Merkel
            97.  Ito T, Udaka N, Yazawa T, Okudela K, Hayashi H, Sudo T, Guillemot   cell polyomavirus small T antigen is an oncoprotein targeting the
                F, Kageyama R, Kitamura H. Basic helix-loop-helix transcription   4E-BP1 translation regulator. J Clin Invest 2011;121:3623-34.
                factors regulate the neuroendocrine differentiation of fetal mouse   114.  Goh G,  Walradt  T, Markarov  V, Blom A, Riaz  N, Doumani R,
                pulmonary epithelium. Development 2000;127:3913-21.  Stafstrom K, Moshiri A, Yelistratova  L, Levinsohn J, Chan  TA,
            98.  Morimoto M, Nishinakamura  R, Saga  Y, Kopan R. Different   Nghiem P, Lifton RP, Choi J. Mutational landscape of MCPyV-
                assemblies of Notch receptors coordinate the distribution of   positive and MCPyV-negative  Merkel cell carcinomas  with
                the major bronchial Clara, ciliated  and neuroendocrine  cells.   implications for immunotherapy. Oncotarget 2016;7:3403-15.
                Development 2012;139:4365-73.                 115.  Harms PW,  Vats P,  Verhaegen  ME, Robinson DR,  Wu  YM,
            99.  Yen  WC, Fischer MM, Axelrod F, Bond C, Cain J, Cancilla  B,   Dhanasekaran SM, Palanisamy N, Siddiqui J, Cao X, Su F, Wang
                Henner WR, Meisner R, Sato A, Shah J, Tang T, Wallace B, Wang   R, Xiao H, Kunju LP, Mehra R, Tomlins SA, Fullen DR, Bichakjian
                M, Zhang C, Kapoun AM, Lewicki J, Gurney A, Hoey T. Targeting   CK, Johnson TM, Dlugosz AA, Chinnaiyan AM. The Distinctive
                Notch signaling with a Notch2/Notch3 antagonist (tarextumab)   Mutational Spectra of Polyomavirus-Negative Merkel Cell
                inhibits tumor growth and decreases tumor-initiating cell frequency.   Carcinoma. Cancer Res 2015;75:3720-7.
                Clin Cancer Res 2015;21:2084-95.              116.  Lemos BD, Storer BE, Iyer JG, Phillips JL, Bichakjian CK, Fang
            100. Graziani I, Eliasz S, De Marco MA, Chen Y, Pass HI, De May RM,   LC, Johnson  TM, Liegeois-Kwon  NJ, Otley  CC, Paulson KG,
                Strack PR, Miele L, Bocchetta M. Opposite effects of Notch-1 and   Ross MI, Yu SS, Zeitouni NC, Byrd DR, Sondak VK, Gershenwald
                Notch-2 on mesothelioma cell survival under hypoxia are exerted   JE, Sober  AJ, Nghiem P. Pathologic nodal evaluation  improves
                through the Akt pathway. Cancer Res 2008;68:9678-85.  prognostic  accuracy in  Merkel  cell  carcinoma:  analysis  of 5823
            101. Yun J, Pannuti A, Espinoza  I, Zhu H, Hicks C, Zhu X, Caskey   cases as the basis of the first consensus staging system. J Am Acad
                M, Rizzo P, D’Souza G, Backus K, Denning MF, Coon J, Sun M,   Dermatol 2010;63:751-61.
                Bresnick EH, Osipo C,  Wu J, Strack PR,  Tonetti DA,  Miele L.   117.  Lemos B, Nghiem P. Merkel cell carcinoma: more deaths but still no
                Crosstalk between  PKCalpha  and Notch-4 in endocrine-resistant   pathway to blame. J Invest Dermatol 2007;127:2100-3.
                breast cancer cells. Oncogenesis 2013;2:e60.  118.  Mauzo SH, Ferrarotto R, Bell D,  Torres-Cabala CA,  Tetzlaff MT,
            102. Parr C, Watkins G, Jiang WG. The possible correlation of Notch-1   Prieto VG, Aung PP. Molecular characteristics and potential therapeutic
                and Notch-2 with clinical outcome and tumour clinicopathological   targets in Merkel cell carcinoma. J Clin Pathol 2016;69:382-90.
                parameters in human breast cancer. Int J Mol Med 2004;14:779-86.  119.  Iyer JG, Parvathaneni U, Gooley T, Miller NJ, Markowitz E, Blom
            103.  Sun J, Deng  WM. Notch-dependent downregulation of the   A, Lewis CW, Doumani RF, Parvathaneni K, Anderson A, Bestick
                homeodomain gene cut is required for the mitotic cycle/endocycle   A, Liao J, Kane G, Bhatia S, Paulson K, Nghiem P. Single-fraction
                switch and cell differentiation in Drosophila follicle cells. Development   radiation therapy in patients with metastatic Merkel cell carcinoma.
                2005;132:4299-308.                                Cancer Med 2015;4:1161-70.
            104. Osipo C, Golde  TE, Osborne BA, Miele LA. Off the beaten   120. Lebbe  C, Becker JC, Grob JJ, Malvehy  J, Del Marmol  V,
                pathway: the complex cross talk between Notch and NF-kappaB.   Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori
                Lab Invest 2008;88:11-7.                          A, Stratigos A, Garbe C, European Dermatology Forum tEAoD-O,
            105. Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS,   the European Organization for R, Treatment of C. Diagnosis and
                Buono K, Salomon D, Vonderhaar BK, Callahan R. Rbpj conditional   treatment  of Merkel  Cell  Carcinoma.  European  consensus-based
                knockout reveals  distinct  functions of Notch4/Int3  in mammary   interdisciplinary guideline. Eur J Cancer 2015;51:2396-403.
                gland development and tumorigenesis. Oncogene 2009;28:219-30.  121. Poulsen M, Rischin D, Walpole E, Harvey J, Mackintosh J, Ainslie
            106. Robinson DR, Kalyana-Sundaram S, Wu YM, Shankar S, Cao X,   J, Hamilton  C,  Keller  J,  Tripcony  L,  Trans-Tasman  Radiation
                Ateeq  B, Asangani IA, Iyer M, Maher CA, Grasso CS, Lonigro   Oncology G. High-risk Merkel cell carcinoma of the skin treated
                RJ, Quist  M, Siddiqui  J, Mehra R, Jing X, Giordano  TJ, Sabel   with synchronous carboplatin/etoposide and radiation:  a  Trans-
                MS, Kleer CG, Palanisamy N, Natrajan R, Lambros MB, Reis-  Tasman Radiation Oncology Group Study -- TROG 96:07. J Clin
                Filho JS, Kumar-Sinha C, Chinnaiyan AM. Functionally recurrent   Oncol 2003;21:4371-6.
                rearrangements  of the MAST kinase and Notch gene families in   122. Tai PT, Yu E, Winquist E, Hammond A, Stitt L, Tonita J, Gilchrist J.
                breast cancer. Nat Med 2011;17:1646-51.           Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin:
            107. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas   case series and review of 204 cases. J Clin Oncol 2000;18:2493-9.
                PF, Nghiem P. Clinical characteristics of Merkel cell carcinoma at   123. Fakiha M, Letertre P, Vuillez JP, Lebeau J. Remission of Merkel
                diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol   cell tumor after somatostatin analog treatment. J Cancer Res Ther
                2008;58:375-81.                                   2010;6:382-4.
            108. Albores-Saavedra J, Batich  K, Chable-Montero  F, Sagy N,   124. Gardair C, Samimi M, Touze A, Coursaget P, Lorette G, Caille A,
                Schwartz AM, Henson DE. Merkel cell carcinoma demographics,   Wierzbicka E, Croue A, Avenel-Audran M, Aubin F, Kerdraon R,
                morphology, and survival based on 3870 cases: a population based   Esteve E, Beneton N, Guyetant S. Somatostatin receptors 2A and
                study. J Cutan Pathol 2010;37:20-7.               5 are expressed in Merkel cell carcinoma with no association with
            109. Miller NJ, Bhatia S, Parvathaneni U, Iyer JG, Nghiem P. Emerging   disease severity. Neuroendocrinology 2015;101:223-35.
                and mechanism-based therapies for recurrent or metastatic Merkel   125. Davids MS, Charlton A, Ng SS, Chong ML, Laubscher K, Dar M,
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