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Topic: Role of Immune Cells in

                                                          the Tumor Microenvironment


                                                          The understanding that immune cells in, or missing from,
                                                          the tumor microenvironment (TME) are a central part
                                                          of  cancer  progression  is  now  well  established.
                                                          However,  in part because these immune cells vary
                                                          so much in types, numbers and function, there are
                                                          certainly large gaps  in  both  general  and  detailed
                                                          understanding of their roles.  Having both broader and
                                                          deeper understanding of the role of immune cells in
               Prof. Steven N. Fiering                    the TME will generate better understanding of cancer
                                                          biology  and  importantly,  will lead to new options

               Department of Microbiology and             for treating tumors with various therapy strategies,
               Immunology, Geisel School of Medicine at   including immunotherapy. Additionally, many studies
               Dartmouth, Lebanon, NH, USA.               have linked immune TME infiltrate  data  in  specific
                                                          cancers  to  patient  outcome  and therapy responses,
                                                          which can guide treatment application. Overall, the
                                                          current phase of cancer research is  heavily  focused  on
                                                          the  TME  and  we  are  confident this Special Issue will
                                                          help expand the understanding of immune cells in the
                                                          TME.     The topic is broad, and we anticipate
                                                          publishing papers on a wide range of subjects grouped
                                                          within  the  “Role  of  immune  cells  in  the  tumor
                                                          microenvironment”.
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