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gastritis fosters the development of intestinal type gastric however, better understanding of the underlying
cancer. [53,54] Thus, these risk factors lead to a state of molecular mechanism needs further investigation.
chronic infl ammation and then development of gastric
cancer. Conclusion
Colorectal Cancer In this review, we have discussed the links between
chronic infl ammation and cancer development, with
CRC is one of the leading causes of cancer-related special reference to GI cancers. Future studies will
deaths in the world. CRC is one of the most serious determine the role for this novel anti-infl ammation
complications of IBD, including ulcerative colitis and treatment modality in the prevention of GI cancers.
Crohn’s disease. The relative risk of CRC in patients
with colitis is two to eight times higher than the Financial support and sponsorship
general population. Although it is clear that chronic This work was supported by Scientifi c Research (C)
[55]
infl ammation is a CRC risk factor, pathogenesis of (KAKENHI) (15K10080) from the Japanese Society for
colitis-associated cancer (CAC) is still uncertain. the Promotion of Science.

CAC develops in chronically infl amed mucosa and is Confl icts of interest
believed to develop in a colitis-dysplasia-carcinoma
sequence. The chronic infl ammation in IBD often results There are no confl icts of interest.
in increased re-epithelialization of cells and cell turnover References
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Journal of Cancer Metastasis and Treatment ¦ Volume 1 ¦ Issue 3 ¦ October 15, 2015 ¦ 141