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Topic: Metastatic Renal Cell

                                                          Carcinoma



                                                          Special Issue Introduction

                                                          Chapter I. SYSTEMIC THERAPIES
                                                          Systemic Therapy for Metastatic Renal-Cell Carcinoma
                                                          Current and emerging therapies for first-line treatment of
                                                          metastatic clear cell renal cell carcinoma
                                                          Advances in second-line targeted therapies for metastatic

               Dr Hendrik Van Poppel                      renal cell carcinoma
                                                          Immunotherapy for metastatic renal cell carcinoma
                                                          Management of Bone metastases of RCC: bone targeted
               Dr Hendrik Van Poppel was the
               Chairman of the Department of Urology      treatment, radiotherapy
               at the University Hospital Gasthuisberg,   Treatment/ management of non-ccRCC
               Katholieke Universiteit (KU) Leuven,
               Belgium, from 2002 until 2015, and         Chapter II. MOLECULAR EN BIOMARKERS
               Co-Chair of the European Cancer            An Update on Predictive Biomarkers in Metastatic Renal
               Organisation’s Inequalities Network.       Cell Carcinoma


               He graduated in General Surgery in         The Identification of Key Gene Expression Signature and
               1980 and in Urology in 1983 and joined     Biological Pathways in Metastatic Renal Cell Carcinoma
               the Academic Unit at KU Leuven after       Individualized therapy for metastatic renal cell carcinoma
               his postgraduate training in London,       Targeted  genomic  landscape  of  metastases compared
               Barcelona, Copenhagen, Mainz and           to primary tumours in clear cell metastatic renal cell
               Rotterdam. In 1988, he obtained a          carcinoma
               PhD in Medical Sciences. He became
               full Professor of Urology in 1993. He
               developed the original surgical technique   Chapter III. SURGERY
               for prepubic urethrectomy, percutaneous    Comparison of immediate vs deferred cytoreductive
               gastrostomy, lumbal splenectomy during     nephrectomy in patients with synchronous metastatic
               orthotopic kidney transplantation, and     renal cell carcinoma
               of theLeuven “N”pouch for bladder          Overview of adjuvant trials
               substitution.
                                                          About value of metastasectomy
               He has published more than 200 papers
               as first author on uro-oncology and has    Chapter IV. Other
               co-authored more than 350 other ones       The landscape of contemporary clinical trials for
               and edited and co-edited several books     untreated metastatic clear cell renal cell carcinoma
               of kidney and prostate cancer. He was      Imaging for Metastatic Renal Cell Carcinoma
               Director of the European School of
               Urology from 2004 to 2012 and Adjunct-     Real-world outcomes of the treatment of metastatic renal
               Secretary General of the European          cell carcinoma
               Association of Urology (EAU) responsible
               for Education 2012-2021.
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