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Table 2. Factors associated with severe COVID-19 and or mortality on multivariable regression analysis #

Factors associated with severe COVID-19 and or mortality
Comorbidities Treatment exposure
Study Cancer type ECOG Cancer status Laboratory
Age Male Smoking Others status variables For COVID For cancer
gender
[13]
Yang et al. All cancers (N = NA OR = 3.86 NA NA NA NA NA NA Cytotoxic chemotherapy*
105) (1.57- (OR = 3.51, 95%CI: 1.16-
9.50), P = 10.59, P = 0.026)
0.0033)
[10]
Mehta et al. All cancers (N = Age < 65 (OR NA NA - Higher composite NA NA Elevated D- NA NA
105) = 0.23, comorbidity dimer, lactate,
95%CI: 0.07- score** (OR = 1.52, and LDH
0.6) 95%CI: 1.02-2.33)
- ICU admission
(OR = 4.83, 95%CI:
1.46-17.15)
[16]
Luo et al. Lung cancer (N = Advancing age NA OR 2.9, - COPD (OR = NA NA NA NA NA
101) (OR = 2.01, 95%CI: 3.87, 95%CI: 1.35-
95%CI: 1.34- 1.07-9.44) 9.68)
3.19) - HTN (OR = 2.68,
95%CI: 1.14-6.14)
[8]
Lee et al. All cancers (N = OR = 9.42, OR = 1.67 NA - HTN (OR = 1.95, NA NA NA NA NA
800) 95%CI: 6.56- (1.19- 1.36-2.80, P <
10.02, P < 2.34), P = 0.001)
0.0001 0.003) - CVD (OR = 2.32,
1.47-3.64)
[7]
Kuderer et al. All cancers (N = Increased age OR = 1.63, OR = 1.60, Number of ECOG 2 or Active cancer Azithromycin +
928) (OR = 1.84, 95%CI: 95%CI: comorbidities (two more (OR = (progressing vs. hydroxychloroquine (vs.
95%CI: 1.53- 1.07-2.48 1.03-2.47 vs. none: OR = 3.89, remission: OR = treatment with neither: OR
2.21) 4.50, 95%CI: 1.33- 95%CI 2.11- 5.20, 95%CI: 2.77- = 2.93, 95%CI: 1.79-4.79)
15.28) 7.18), 9.77)
[11,20]
Garassino et al. Lung cancer (N = Age > 65 (OR NA NA NA ECOG ≥ 1 NA NA NA Use of steroids
400) = 1.70, 95%CI: (OR = 2.14, (equivalent of prednisone
1.09-2.63, P = 95%CI: 1.11- > 10 mg/day) (OR =
0.018) 4.11, P < 1.49, 95%CI: 1.00-2.23, P
0.001) = 0.052)
Chemotherapy (+ or -
immunotherapy) (OR =
1.71, 95%CI: 1.12-2.63, P
= 0.025)

#
- Only positive associations reported. *Within 4 weeks before symptom onset; **Composite score defined as the sum of indicators for diabetes mellitus (DM), hypertension, chronic lung disease, chronic kidney
disease, coronary artery disease, and congestive heart failure capped at a maximum of 3. NA: Not applicable; OR: odds ratio; CI: confidence interval; ICU: intensive care unit; LDH: lactate dehydrogenase; COPD:
chronic obstructive pulmonary disease; HTN: hypertension; ECOG: Eastern Cooperative Oncology Group.