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Figure 4. Summary of the IC 50 values for Topotecan and cell lines either as medium controls or supplemented with MAT (Error bars are
represented by mean values ± SD; all differences are statistically significant)
Figure 5. Size distribution of MAT derived from BHGc91 SCLC CTCs. The insert depicts a SEM preparation of BHGc91 MAT (magnification
2000×, the bar represents 10 µm). CTCs: circulating tumor cells; SCLC: small-cell lung cancer; MAT: material
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from 4.3 to 5.2 months. This constitutes a significant but minor improvement . In most cases, SCLC has
excellent response to platinum-based first-line treatment but it invariably recurs as drug-resistant tumor
