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Page 8 of 12 Herrera et al. J Cancer Metastasis Treat 2018;4:42 I http://dx.doi.org/10.20517/2394-4722.2018.35

This synergism also accelerates the acquisition of heterogeneity whereby increases in genomic heterogeneity
will promote heterogeneity of mitochondria function, and vice versa.

DECLARATIONS
Acknowledgments
The authors would like to thank Dr. Sid Das and the Das lab for continuous support and helpful discussions.

Authors’ contributions
All authors contributed to the writing of this review. In addition Herrera EL prepared the figures.

Availability of data and materials
Not applicable.

Financial support and sponsorship
Work in our laboratory is partially funded by UTEP’s Research Incentive Program and a grant to LADM
from BD-Biosciences. Herrera EL is an NIGS RISE-scholar funded by grant R25GM069621-11. Azzam SZ is
an NSF S-STEM scholar funded by grant DUE1565063.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2018.

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