Page 307 - Read Online
P. 307
Page 14 of 15 Song et al. Hepatoma Res 2020;6:27 I http://dx.doi.org/10.20517/2394-5079.2020.05
switch jobs? Cold Spring Harb Perspect Biol 2018;10.
99. Harmon C, Robinson MW, Fahey R, Whelan S, Houlihan DD, et al. Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with
reduced proinflammatory potential are enriched in the adult human liver. Eur J Immunol 2016;46:2111-20.
100. Stegmann KA, Robertson F, Hansi N, Gill U, Pallant C, et al. CXCR6 marks a novel subset of T-bet(lo)Eomes(hi) natural killer cells
residing in human liver. Sci Rep 2016;6:26157.
101. Ju Y, Hou N, Meng J, Wang X, Zhang X, et al. T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates
natural killer cell suppression in chronic hepatitis B. J Hepatol 2010;52:322-9.
102. Li H, Zhai N, Wang Z, Song H, Yang Y, et al. Regulatory NK cells mediated between immunosuppressive monocytes and
dysfunctional T cells in chronic HBV infection. Gut 2018;67:2035-44.
103. Yang Y, Han Q, Hou Z, Zhang C, Tian Z, et al. Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction. Cell
Mol Immunol 2017;14:465-75.
104. Shi J, Zhao J, Zhang X, Cheng Y, Hu J, et al. Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-beta-
dependent emperipolesis in HBV cirrhotic patients. Sci Rep 2017;7:44544.
105. Zhong R, Tian J, Fu M, Ma S, Liu L, et al. LINC01149 variant modulates MICA expression that facilitates hepatitis B virus
spontaneous recovery but increases hepatocellular carcinoma risk. Oncogene 2020;39:1944-56.
106. Cepero-Donates Y, Lacraz G, Ghobadi F, Rakotoarivelo V, Orkhis S, et al. Interleukin-15-mediated inflammation promotes non-
alcoholic fatty liver disease. Cytokine 2016;82:102-11.
107. Cuff AO, Sillito F, Dertschnig S, Hall A, Luong TV, et al. The obese liver environment mediates conversion of NK cells to a less
cytotoxic ILC1-like phenotype. Front Immunol 2019;10:2180.
108. Amer J, Salhab A, Noureddin M, Doron S, Abu-Tair L, et al. Insulin signaling as a potential natural killer cell checkpoint in fatty liver
disease. Hepatol Commun 2018;2:285-98.
109. Tosello-Trampont AC, Krueger P, Narayanan S, Landes SG, Leitinger N, et al. NKp46(+) natural killer cells attenuate metabolism-
induced hepatic fibrosis by regulating macrophage activation in mice. Hepatology 2016;63:799-812.
110. Li Y, Tang L, Guo L, Chen C, Gu S, et al. CXCL13-mediated recruitment of intrahepatic CXCR5(+)CD8(+) T cells favors viral
control in chronic HBV infection. J Hepatol 2020;72:420-30.
111. Salimzadeh L, Le Bert N, Dutertre CA, Gill US, Newell EW, et al. PD-1 blockade partially recovers dysfunctional virus-specific B
cells in chronic hepatitis B infection. J Clin Invest 2018;128:4573-87.
112. Burton AR, Pallett LJ, McCoy LE, Suveizdyte K, Amin OE, et al. Circulating and intrahepatic antiviral B cells are defective in
hepatitis B. J Clin Invest 2018;128:4588-603.
113. Kim HD, Song GW, Park S, Jung MK, Kim MH, et al. Association between expression level of PD1 by tumor-infiltrating CD8(+) T
cells and features of hepatocellular carcinoma. Gastroenterology 2018;155:1936-50.e17.
114. Wang X, He Q, Shen H, Xia A, Tian W, et al. TOX promotes the exhaustion of antitumor CD8(+) T cells by preventing PD1
degradation in hepatocellular carcinoma. J Hepatol 2019;71:731-41.
115. Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, et al. Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing.
Cell 2017;169:1342-56.e16.
116. Kim GA, Lim YS, Han S, Choi J, Shim JH, et al. High risk of hepatocellular carcinoma and death in patients with immune-tolerant-
phase chronic hepatitis B. Gut. 2018;67:945-52.
117. Ghazarian M, Revelo XS, Nohr MK, Luck H, Zeng K, et al. Type I interferon responses drive intrahepatic T cells to promote
metabolic syndrome. Sci Immunol 2017;2:pii: eaai7616.
118. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, et al. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Nature 2017;551:340-5.
119. Meng F, Zhen S, Song B. HBV-specific CD4+ cytotoxic T cells in hepatocellular carcinoma are less cytolytic toward tumor cells and
suppress CD8+ T cell-mediated antitumor immunity. APMIS 2017;125:743-51.
120. Wang X, Dong Q, Li Q, Li Y, Zhao D, et al. Dysregulated response of follicular helper T cells to hepatitis B surface antigen promotes
HBV persistence in mice and associates with outcomes of patients. Gastroenterology 2018;154:2222-36.
121. Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, et al. An OX40/OX40L interaction directs successful immunity to
hepatitis B virus. Sci Transl Med 2018;10.
122. Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, et al. OX40 stimulation and PD-L1 blockade synergistically augment HBV-
specific CD4 T cells in patients with HBeAg-negative infection. J Hepatol 2019;70:1103-13.
123. Walker CM, Lemon SM. Getting the skinny on CD4(+) T cell survival in fatty livers. Immunity 2016;44:725-7.
124. Brown ZJ, Fu Q, Ma C, Kruhlak M, Zhang H, et al. Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4(+)
T cell apoptosis promoting HCC development. Cell Death Dis 2018;9:620.
125. Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, et al. NAFLD causes selective CD4(+) T lymphocyte loss and
promotes hepatocarcinogenesis. Nature 2016;531:253-7.
126. Vanwolleghem T, Hou J, van Oord G, Andeweg AC, Osterhaus AD, et al. Re-evaluation of hepatitis B virus clinical phases by systems
biology identifies unappreciated roles for the innate immune response and B cells. Hepatology 2015;62:87-100.
127. Bertoletti A, Ferrari C. Adaptive immunity in HBV infection. J Hepatol 2016;64:S71-83.
128. Zhang S, Zhao J, Zhang Z. Humoral immunity, the underestimated player in hepatitis B. Cell Mol Immunol 2018;15:645-8.
129. Poonia B, Ayithan N, Nandi M, Masur H, Kottilil S. HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T
follicular helper cell axis. Sci Rep 2018;8:15296.
130. Tout I, Gomes M, Ainouze M, Marotel M, Pecoul T, et al. Hepatitis B virus Blocks the CRE/CREB Complex and Prevents TLR9
Transcription and Function in Human B Cells. J Immunol 2018;201:2331-44.
131. Schwenger KJP, Chen L, Chelliah A, Da Silva HE, Teterina A, et al. Markers of activated inflammatory cells are associated with