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Acknowledgments The central acidic domain of MDM2 is critical in inhibition of
We thank Alejandro Parrales and Swathi V. Iyer for editing the retinoblastoma-mediated suppression of E2F and cell growth. J Biol Chem
manuscript and helpful discussion. 2004;279:53317-22.
21. Gu L, Findley HW, Zhou M. MDM2 induces NF-kappaB/p65 expression
Financial support and sponsorship transcriptionally through Sp1-binding sites: a novel, p53-independent role
of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia.
This project is supported by NIH 1-R01-CA174735-01A1 (T.I.) Blood 2002;99:3367-75.
and 5-P30-CA168524-02 (PI: Roy A. Jensen) grants. 22. Johnson-Pais T, Degnin C, Thayer MJ. pRB induces Sp1 activity by
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There are no conflicts of interest. 23. Riley MF, Lozano G. The many faces of MDM2 binding partners. Genes
Cancer 2012;3:226-39.
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