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Aronson et al. Hepatoma Res 2022;8:22 Hepatoma Research
DOI: 10.20517/2394-5079.2022.20

Editorial Open Access

Liver tumors in children

1
Daniel C. Aronson , Piotr Czauderna 2
1
(retired) Department of Paediatric Surgery, University Children’s Hospital Zürich, Zürich 8032, Switzerland.
2
Department of Surgery and Urology, Children and Adolescents Medical University of Gdansk, Gdansk 80-803, Poland.
Correspondence to: Prof. Daniel C. Aronson, Department of Paediatric Surgery, University Children’s Hospital Zürich,
Steinwiesstrasse 75, Zürich 8032, Switzerland.
How to cite this article: Aronson DC, Czauderna P. Liver tumors in children. Hepatoma Res 2022;8:22.
https://dx.doi.org/10.20517/2394-5079.2022.20
Received: 15 Apr 2022 Accepted: 21 Apr 2022 Published: 7 May 2022

Academic Editor: Guang-Wen Cao Copy Editor: Tiantian Shi Production Editor: Tiantian Shi

This issue of Hepatoma Research is dedicated to liver tumors in Children, which is a quite rare group of
tumors. Although the majority of pediatric liver tumors are malignant (57%), its main contributors,
hepatoblastoma (HB) and hepatocellular carcinoma (HCC), only have an incidence of 1.6 per 1 million
children, thus comprising 5%-8% of all pediatric solid tumors.

Our goal has been to establish an issue for the journal that gives a state-of-the-art overview of some aspects
[1]
of the current knowledge within this field. The paper of Armengol et al. overviews some basic science,
bridging molecular biology to the prognosis and treatment of HB. Surgical aspects are described by the
literature review of Kościuszko et al. , who give an overview of preoperative planning of liver tumor
[2]
resections, Hiyama et al. , who describe the consequences of marginal positive resection margins, and
[3]
[5]
[4]
Calinescu et al. , who describe the role of liver transplantation in Pediatric HB and HCC. Weeda et al.
give an overview of where we stand with HCC, and Calinescu et al. describe the surgical perspective of
[6]
undifferentiated sarcoma of the liver.
The way forward in the approach to rare tumors is an international collaboration. It has been this
international cooperation between the four major Pediatric Liver Tumor Study Groups in Europe, the USA,
and Japan (SIOPEL/GPOH, COG, and JPLT) that formed the tipping point to create the Children’s Hepatic
tumor International Collaborative (CHIC), leading to the establishment of a large international
[7]
collaborative dataset, the CHIC database . This database contains such a large data set, that its analysis

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0
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