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Page 16 of 21 Toniutto et al. Hepatoma Res 2020;6:50 I http://dx.doi.org/10.20517/2394-5079.2020.40

From a clinical perspective, the search for the perfect solution between expanding the Milan criteria and
maintaining a sufficiently low risk of tumor recurrence to allow a patient survival rate of at least 60% at
5 years represents a major challenge for the coming years. The models used to predict the risk of HCC
recurrence based on the pre-transplant evaluation of all tumor characteristics (including its response to
treatments) currently represent those that combine both rigorous aspects of patient selection and organ
allocation for transplant. These two factors work synergistically to increase the benefit, effectiveness, and
justice of transplantation for HCC. The evaluation of the results obtained by adopting these criteria on large
patient series in different geographical areas will be crucial for defining their validity and applicability.

DECLARATIONS
Authors’ contributions
Wrote the paper: Toniutto P
Selected bibliography and collaborate in writing the paper: Fornasiere E, Fumolo E, Bitetto D

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

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