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Topic: Liver Cancer in
Alcoholic and Metabolic Liver
Diseases
It is my pleasure to present this special issue of
Hepatoma Research which focused on Liver Cancer in
Alcoholic and Metabolic Liver Diseases. As most are
aware, Hepatocellular carcinoma is the most common
primary liver malignancy, and the incidence of this
condition is increasing worldwide. Most liver cancers
develop in the presence of underlying liver disease.
The emergence of non-alcoholic fatty liver disease,
continuing high global rates of alcohol consumption
and the high prevalence of iron overload disease in
Caucasian populations and their clear association with
hepatocellular carcinoma has focused attention on the
need for ongoing research in the field. This edition
Darrell Crawford, MD of Hepatoma Research addresses fundamental areas
Associate Dean (Strategic of study in the field of Liver Cancer in Alcoholic and
Development), Faculty of Medicine, Metabolic Liver Diseases. Issues that are discussed
The University of Queensland, in the following chapters include relevant animal
Queensland, Australia.
Director of Research, Gallipoli models of liver cancer, emerging concepts around
Medical Research Foundation, the epidemiology of hepatocellular carcinoma in
Greenslopes Private Hospital, metabolic liver diseases, current knowledge of the
Greenslopes, Queensland, Australia.
molecular basis of liver cancer in these conditions and
our current understanding of the relationship between
iron overload and liver cancer.
The authors have presented an excellent series of
reviews that should inform future progress in the field.
I wish to thank each contributor for their fine work. I
highly recommend this issue of the journal.
