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Page 8 of 16 Teschke. Hepatoma Res 2019;5:40 I http://dx.doi.org/10.20517/2394-5079.2019.0017

Table 3. Selected substrates of the hepatic microsomal CYP 2E1
Selected substrates catalyzed by CYP 2E1
Acetaldehyde
Acetol
Acetone
Acetaminophen
Aniline
Benzene
Bromobenzene
n-Butanol
Caffeine
Carbon tetrachloride
Chloroform
1-Chloropropane
Chlorzoxazone
1,1-Dichloroethane
1,2-Dichloroethane
1,1-Dichloroethylene
cis-1,2-Dichloroethylene
trans-1,2-Dichloroethylene
Dichloromethane
1,2-Dichloropropane
1,2-Dibromoethane
Diethylether
Dimethylformamide
Cumene
Enflurane
Ethanol
Ethylbenzene
Halothane
n-Hexane
Isoflurane
Methanol
Methyl t-butyl ether
Methoxyflurane
Monochlorobenzene
4-Nitrophenol
p-Nitrophenol
Nitrosamines
N-nitrosodimethylamine
n-Pentane
Phenol
n-Propanol
Propylbenzene
Sevoflurane
Styrene
1,1,1,2-Tetrachloroethane
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
Toluol
Trichloroethylene
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Vinylchloride
o,m,p-Xylene
Listed chemicals are preferred substrates of CYP 2E1. Data are derived
from a previous report that provides exact references for each listed
substance [16] . CYP 2E1: cytochrome P450 2E1