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Topic: SBRT and

                                                          Immunotherapy for the

                                                          Management of HCC: A

                                                          Recent Appraisal

                      Guest Editor:
                      Jia Fan, MD
                                                          Hepatocellular carcinoma (HCC) is the most
                Department of Liver Surgery and
                  Transplantation, Liver Cancer           frequent  primary liver  cancer, leading to more
               Institute, Zhongshan Hospital, Fudan       than 700 thousand deaths annually. In recent
                  University, Shanghai, China.            years, immunotherapy has emerged as a novel,
                President of Shanghai Zhongshan           effective  systemic  treatment  for advanced HCC,
                   Hospital, Shanghai, China.
               Academician of Chinese Academy of          which can potentially suppress tumor recurrence
                          Sciences                        and metastasis. However, the objective response
                                                          rate of simply immunologic agent treatment for
                                                          HCC is still unsatisfactory. The combination of
                                                          conventional treatments including stereotactic
                                                          body  radiation  therapy  (SBRT)  with  specific
                                                          immunotherapeutic approaches may dramatically
                                                          improve outcome of HCC patients. Moreover, the
                                                          advancement of SBRT techniques has allowed
                                                          for a safer administration of higher levels of dose
                                                          to liver cancer while minimizing the potential
                   Academic Editor:                       liver toxicities. In this edition of Hepatoma
                  Ying-Hong Shi, MD                       Research, we will discuss new advances in SBRT,
                                                          immunotherapy, and combined strategies for the
                Department of Liver Surgery and
                  Transplantation, Liver Cancer           treatment of patients with liver cancer.
               Institute, Zhongshan Hospital, Fudan
                  University, Shanghai, China.
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