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Carvalho et al. Hepatoma Res 2018;4:15  I  http://dx.doi.org/10.20517/2394-5079.2018.13                                            Page 5 of 6


               The majority of the clinical information was obtained from patient records, and some of the patients
               presented incomplete data.


               In conclusion, the frequency of HCC-NC in these Brazilian patients was elevated and more commonly
               observed in men. HCV, NASH, and HBV were the most frequent risk factors associated with HCC-NC.
               These data contribute to discussions on future protocols and criteria for the early diagnosis and treatment of
               HCC patients with chronic liver disease without cirrhosis.


               DECLARATIONS
               Authors’ contributions
               Concept and design: Cotrim HP
               Data acquisition: Carvalho KSD, Fonseca LE
               Data analysis: Carvalho KSD, Cotrim HP
               Manuscript preparation: Carvalho KSD, Cotrim HP
               Critical revision and finalizing of the manuscript: Cotrim HP

               Data source and availability
               The data were strictly obtained from medical records according to the privacy policy and ethics code of our
               institute.

               Financial support and sponsorship
               None.


               Conflicts of interest
               There are no conflicts of interest.


               Patient consent
               Consents from all of the patients were established prior to submission and all records were confidential.

               Ethics approval
               The present study was approved by the Ethics Committee and Research at Bahia School of Medicine,
               Universidade Federal da Bahia, Brazil.

               Copyright
               © The Author(s) 2018.


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