Page 80 - Read Online
P. 80

Page 10 of 10                 Ruff et al. Hepatoma Res 2023;9:37  https://dx.doi.org/10.20517/2394-5079.2023.51

                   therapeutic targets. Ann Surg Oncol 2014;21:3827-34.  DOI  PubMed  PMC
               30.      Boerner T, Drill E, Pak LM, et al. Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma. Hepatology 2021;74:1429-
                   44.  DOI  PubMed  PMC
               31.      Goyal L, Govindan A, Sheth RA, et al. Prognosis and clinicopathologic features of patients with advanced stage isocitrate
                   dehydrogenase (IDH) mutant and IDH wild-type intrahepatic cholangiocarcinoma. Oncologist 2015;20:1019-27.  DOI  PubMed  PMC
               32.      Churi CR, Shroff R, Wang Y, et al. Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications. PLoS One
                   2014;9:e115383.  DOI  PubMed  PMC
               33.      Zhu  AX,  Macarulla  T,  Javle  MM,  et  al.  Final  overall  survival  efficacy  results  of  ivosidenib  for  patients  with  advanced
                   cholangiocarcinoma with idh1 mutation: the phase 3 randomized clinical clarIDHy trial. JAMA Oncol 2021;7:1669-77.  DOI  PubMed
                   PMC
               34.      Cleary JM, Rouaisnel B, Daina A, et al. Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired
                   resistance to ivosidenib in cholangiocarcinoma. NPJ Precis Oncol 2022;6:61.  DOI  PubMed  PMC
               35.      Lowery  MA,  Burris  HA  3rd,  Janku  F,  et  al.  Safety  and  activity  of  ivosidenib  in  patients  with  IDH1-mutant  advanced
                   cholangiocarcinoma: a phase 1 study. Lancet Gastroenterol Hepatol 2019;4:711-20.  DOI  PubMed  PMC
               36.      NCCN guidelines version: hepatobiliary cancers. 2022. Available from: https://www.nccn.org/guidelines/guidelines-detail?category=
                   1&id=1438 [Last accessed on 31 Jul 2023].
               37.      Salama V, Brooks N, Skwarska A, et al. Abstract 6417: LY3410738, a novel inhibitor of mutant IDH1 is more effective than
                   Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML).
                   Cancer Res 2020;80:6417.  DOI
               38.      Pauff JM, Papadopoulos KP, Janku F, et al. A phase I study of LY3410738, a first-in-class covalent inhibitor of mutant IDH1 in
                   cholangiocarcinoma and other advanced solid tumors. J Clin Oncol 2021;39:TPS350.  DOI
               39.      Wang Y, Wild AT, Turcan S, et al. Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas
                   and cholangiocarcinomas. Sci Adv 2020;6:eaaz3221.  DOI  PubMed  PMC
               40.      Schvartzman JM, Reuter VP, Koche RP, Thompson CB. 2-hydroxyglutarate inhibits MyoD-mediated differentiation by preventing
                   H3K9 demethylation. Proc Natl Acad Sci U S A 2019;116:12851-6.  DOI  PubMed  PMC
               41.      Sharma H. Development of novel therapeutics targeting isocitrate dehydrogenase mutations in cancer. Curr Top Med Chem
                   2018;18:505-24.  DOI  PubMed
               42.      Stewart MD, Merino Vega D, Arend RC, et al. Homologous recombination deficiency: concepts, definitions, and assays. Oncologist
                   2022;27:167-74.  DOI  PubMed  PMC
               43.      Niger M, Nichetti F, Casadei-Gardini A, et al. Platinum sensitivity in patients with IDH1/2 mutated vs wild-type intrahepatic
                   cholangiocarcinoma: a propensity score-based study. Int J Cancer 2022;151:1310-20.  DOI
               44.      Saha SK, Gordan JD, Kleinstiver BP, et al. Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence
                   in intrahepatic cholangiocarcinoma. Cancer Discov 2016;6:727-39.  DOI  PubMed  PMC
               45.      Fujiwara H, Tateishi K, Kato H, et al. Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET
                   inhibitor JQ1. Cancer Sci 2018;109:3602-10.  DOI  PubMed  PMC
               46.      Zeng L, Zhou MM. Bromodomain: an acetyl-lysine binding domain. FEBS Lett 2002;513:124-8.  DOI  PubMed
               47.      Choe S, Wang H, DiNardo CD, et al. Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant
                   relapsed or refractory AML. Blood Adv 2020;4:1894-905.  DOI  PubMed  PMC
               48.      Wang F, Morita K, DiNardo CD, et al. Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute
                   myeloid leukemia. Nat Commun 2021;12:2607.  DOI  PubMed  PMC
               49.      Harding JJ, Lowery MA, Shih AH, et al. Isoform switching as a mechanism of acquired resistance to mutant isocitrate dehydrogenase
                   inhibition. Cancer Discov 2018;8:1540-7.  DOI  PubMed  PMC
   75   76   77   78   79   80   81   82   83   84   85