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Zhang et al. Hepatoma Res 2023;9:5 Hepatoma Research
DOI: 10.20517/2394-5079.2023.11

Editorial Open Access

Improve the precise pathological diagnosis of

intrahepatic cholangiocarcinoma: introduction to
2022 expert consensus on pathological diagnosis of

intrahepatic cholangiocarcinoma in China

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Xin Zhang , Han Wang , Jun Chen , Xia Sheng , Hongqi Zhang , Lihong Zhang , Wenming Cong , Ji Yuan 1
1
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
2
Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China.
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Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, Jiangsu,
China.
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Department of Pathology, Minhang Hospital, Fudan University, Shanghai 201100, China.
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Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Correspondence to: Prof. Wenming Cong, Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical
University, 225 Changhai Road, Shanghai 200438, China. E-mail: wmcong@smmu.edu.cn; Prof. Ji Yuan, Department of
Pathology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. E-mail: ji.yuan@zs-hospital.sh.cn
How to cite this article: Zhang X, Wang H, Chen J, Sheng X, Zhang H, Zhang L, Cong W, Yuan J. Improve the precise
pathological diagnosis of intrahepatic cholangiocarcinoma: introduction to 2022 expert consensus on pathological diagnosis of
intrahepatic cholangiocarcinoma in China. Hepatoma Res 2023;9:5. https://dx.doi.org/10.20517/2394-5079.2023.11
Received: 13 Feb 2023 Accepted: 3 Mar 2023 Published: 9 Mar 2023
Academic Editor: Guang-Wen Cao Copy Editor: Ying Han Production Editor:Ying Han

Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive intrahepatic epithelial neoplasm with biliary
differentiation. The clinicopathological characteristics of ICC and extrahepatic cholangiocarcinoma are
significantly different . In the last 10 years, notable progress has been made in the pathological research of
[1]
ICC, and some of them have been compiled by the 5th edition of the World Health Organization (WHO)
Classification of Tumors of the Digestive System. However, the diagnostic strategy of ICC in the current
WHO classification still has something to be further refined for routine practice. In order to standardize the
pathological diagnosis of ICC and provide an elaborate pathological basis for personalized treatment in the
clinic, 46 experts in the field of liver tumors, representing seven professional societies/academic groups of
China, including pathology, surgery, oncology, and basic disciplines, developed the expert consensus on
[2]
ICC pathological diagnosis .

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