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Table 3. MiRNAs in cis- and carboplatin resistance
miRNAs -regulation Targets Ref.
Cisplatin resistance
miR-7 Down- MAFG [106]
let7e Down- BRCA1, Rad51 [108,109]
miR-9 De- BRCA1 [110,111]
miR-21 Up- NAV3, PTEN, c-IAP2, PDCD4 [112,147-149]
miR-23a Up- n.d. [113]
miR-24-3p, Up- MAPK signaling pathway [150]
miR-192-5p, Up BRCA1, RB1, CDK1, ABL1, CCNA1
miR-139-5p, Down- MET, SHC1, EGFR, INPPL1
miR-155-5p Down- MET, SHC1, EGFR, INPPL1
miR-29 Down- n.d. [151]
miR-30a/c Down- DNMT1, Snail [152]
miR-30a-5p, Up- n.d. [153]
miR-34c-5p
miR-31 Up- KCNMA1 [114]
miR-34a Down- HDAC1 [115]
miR-93 Down- DNA polymerase η [154]
miR-101 Down- EZH2 [155]
miR-106a Up-/down- PDCD4/MCL1 [156,157]
miR-125b Up- BAK1 [158]
miR-128 Down- Bmi-1, ABCC5 [116]
miR-130a Down-/up- MDR1, PTEN, XIAP [159-162]
miR-130b Down- CSF-1, MDR1, GST-π [117,163]
miR-133b Down- MDR1, GST-π [164]
miR-136 Down- n.d. [118]
miR-139-5p Down- c-Jun [122]
miR-141 Up- KEAP1 [124]
miR-142-5p Down- XIAP, BIRC3, BCL2, BCL2L2, MCL1 [165]
miR-149-5p Up- MST1, SAV1 [166]
miR-152 Down- ERCC1 [167]
miR-152 Down- DNMT1 [168]
miR-185
miR-186 Down- MDR1 (ABCB1), GST-π, Twist1 [169,170]
miR-199a Down- DDR1, ITGB8, mTOR [125,171,172]
miR-199b-5p Down- Jagged1 [173]
miR-204 Down- IL-6 receptor [174]
miR-224-5p Up- protein kinase C [126]
miR-330-5p Down- S100A7 [175]
miR-335-5p Down- BCL2L2 [176]
miR-363 Down- Snail [177]
miR-376c Up- ALK7 [178]
miR-429 Down- ZEB1 [179]
miR-449a Down- NOTCH1 [127]
miR-483-3p Up- protein kinase Cd [128]
miR-489 Down- Akt3 [180]
miR-490-3p Down- ABCC2 [181]
miR-497 Down- mTOR, p70S6K1 [182]
MiR-509-3p Down- GOLPH3, WLS [131]
miR-520g Up- DAPK2 [132]
miR-551b Up- FOXO3, TRIM31 [134]
miR-634 Down- CCND1, GRB2, ERK2, RSK2 [183]
miR-708 Down- IGF2BP1 [184]
miR-770-5p Down- ERCC2 [136]
miR-873 Down- MDR1 (ABCB1) [185]
miR-1294 Down- IGF-1 receptor [138]
Carboplatin resistance
miR-146a Down- n.d. [140]