Page 81 - Read Online

Zeng et al. Cancer Drug Resist 2024;7:31 https://dx.doi.org/10.20517/cdr.2024.57 Page 5 of 13

Table 1. circRNAs associated with proliferation, invasion, and metastasis in HNSCC
circRNA Expression Functions Targets Tumor Ref.
circITCH Downregulation Proliferation;metastasis; invasion miR-214 NPC [32]
circRNF13 Downregulation Proliferation;metastasis SUMO2 [54]
circCCNB1 Downregulation Metastasis; invasion Nuclear factor 90 [57]
hsa-circ-0000345 Downregulation Proliferation; metastasis; invasion miR-513a-3p [58]
circTGFBR2 Downregulation Proliferation; metastasis miR-107 [59]
circ-0046263 Upregulation Proliferation; metastasis miR-133a-5p [21]
circZNF609 Upregulation Proliferation; metastasis; invasion; miR-188; miR-150-5p; miR-145 [22-24]
angiogenesis
circTRAF3 Upregulation Proliferation; metastasis miR-203a-3p [26]
circRPMS1 Upregulation Proliferation; invasion; EMT miR-203; miR-31; miR-451 [27]
circKIAA0368 Upregulation Proliferation; metastasis; invasion; EMT miR-6838p-5p [28]
circ-0004788 Upregulation Proliferation; metastasis; invasion; miR-515-5p [29]
angiogenesis
circ-0081534 Upregulation Proliferation; migration; invasion; EMT miR-874-3p; miR-508-5p [30,31]
circCTDP1 Upregulation Proliferation; metastasis; invasion; miR-320b [52]
apoptosis
circARHGAP12 Upregulation Metastasis; invasion EZR; TPM3; RhoA [53]
circSETD3 Upregulation Metastasis; invasion; proliferation miR-615-5; miR-1538; miR-147a [34,35]
circ-0000215 Upregulation Proliferation; metastasis miR-512-5p [55]
circCAMSAP1 Upregulation Proliferation; metastasis SERPINH1 [56]
circTMTC1 Upregulation Proliferation; migration; invasion; EMT; miR-495 [25]
apoptosis
circHIPK3 Upregulation Proliferation; metastasis; invasion miR-4288 [33]
circRILPL1 Upregulation Proliferation; metastasis ROCK1; IPO7 [61]
circPVT1 Upregulation Metastasis; invasion E3 ubiquiting ligase β-TrCP [60]
circ-0000140 Downregulation Proliferation; metastasis; invasion miR-182-5p OSCC [43]
hsacirc0001971/hsa-circ- Upregulation Proliferation; apoptosis miR-194; miR-204; miR-186/ [38]
0001874 miR-296
circPKD2 Downregulation Proliferation; metastasis; invasion miR-204-3p [49,50]
hsa-circ-0002203 Downregulation Proliferation; metastasis; invasion; / [41]
apoptosis
hsa-circ-0004491 Downregulation Metastasis; invasion / [40]
hsa-circ-0007059 Downregulation Proliferation; metastasis; invasion AKT/mTOR [44]
hsa-circ-0055538 Downregulation Proliferation p53/Bcl-2/caspase [45]
hsa-circ-0063772 Downregulation Proliferation; metastasis; invasion / [42]
hsa-circ-0092125 Downregulation Proliferation; metastasis; invasion / [46]
circ-100290 Upregulation Proliferation; glycolysis miR-29b; miR-378a [47,48]
circDOCK1 Upregulation Proliferation miR-196a-5p [37]
circHIPK3 Upregulation Proliferation; metastasis; invasion; EMT; miR-124; miR-381-3p; miR-637 [36]
apoptosis
hsa-circ-0001971 Upregulation Proliferation; apoptosis miR-186; miR-107 [19,62,
63]
hsa-circ-0011946 Upregulation Proliferation; metastasis; invasion miR3383p [39]
circPARD3 Downregulation Proliferation / LSCC [68]
circ-0036722 Downregulation Proliferation miR-1248 [66]
circ-100290 Upregulation Proliferation miR-29a-3p [51]
circSHKBP1 Upregulation Proliferation; invasion miRNA-766-5p [64]
circ-0005033 Upregulation Proliferation; metastasis; invasion miR-107 [70]
circ-0044520 Upregulation Proliferation; metastasis; invasion miR-338-3p [71]
circ-0023028 Upregulation Proliferation; metastasis miR-486-3p [72]
circ-103862 Upregulation Proliferation; invasion miR-493-5p [65]