Page 31 - Read Online
P. 31
Page 24 of 28 Cheng et al. Cancer Drug Resist. 2025;8:46
65. Xu Y, Wang X, Liu L, Wang J, Wu J, Sun C. Role of macrophages in tumor progression and therapy (Review). Int J Oncol. 2022;60:57.
DOI PubMed PMC
66. Xu Y, Zeng H, Jin K, et al. Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and
therapeutic vulnerability in patients with muscle-invasive bladder cancer. J Immunother Cancer. 2022;10:e003416. DOI PubMed PMC
67. Xue VW, Chung JY, Córdoba CAG, et al. Transforming growth factor-β: a multifunctional regulator of cancer immunity. Cancers.
2020;12:3099. DOI PubMed PMC
68. Viola A, Munari F, Sánchez-Rodríguez R, Scolaro T, Castegna A. The metabolic signature of macrophage responses. Front Immunol.
2019;10:1462. DOI PubMed PMC
69. Xiao L, Wang Q, Peng H. Tumor-associated macrophages: new insights on their metabolic regulation and their influence in cancer
immunotherapy. Front Immunol. 2023;14:1157291. DOI PubMed PMC
70. Bied M, Ho WW, Ginhoux F, Blériot C. Roles of macrophages in tumor development: a spatiotemporal perspective. Cell Mol Immunol.
2023;20:983-92. DOI PubMed PMC
71. Wu Q, Zhou W, Yin S, et al. Blocking triggering receptor expressed on myeloid cells-1-positive tumor-associated macrophages induced
by hypoxia reverses immunosuppression and anti-programmed cell death ligand 1 resistance in liver cancer. Hepatology.
2019;70:198-214. DOI PubMed PMC
72. Lubitz GS, Brody JD. Not just neighbours: positive feedback between tumour-associated macrophages and exhausted T cells. Nat Rev
Immunol. 2022;22:3. DOI PubMed
73. Kersten K, Hu KH, Combes AJ, et al. Spatiotemporal co-dependency between macrophages and exhausted CD8 T cells in cancer.
+
Cancer Cell. 2022;40:624-38.e9. DOI PubMed PMC
74. Nixon BG, Kuo F, Ji L, et al. Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in
cancer. Immunity. 2022;55:2044-58.e5. DOI PubMed PMC
75. Nagaraj S, Gupta K, Pisarev V, et al. Altered recognition of antigen is a mechanism of CD8 T cell tolerance in cancer. Nat Med.
+
2007;13:828-35. DOI PubMed PMC
76. Li J, Wang L, Chen X, et al. CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in
patients with non-small cell lung cancer. OncoImmunology. 2017;6:e1320011. DOI PubMed PMC
77. Hoskin D, Mader J, Furlong S, Conrad D, Blay J. Inhibition of T cell and natural killer cell function by adenosine and its contribution to
immune evasion by tumor cells (Review). Int J Oncol. 2008;32:527-35. PubMed
78. Xu S, Wang C, Yang L, et al. Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy. Front
Immunol. 2023;14:1199631. DOI PubMed PMC
79. Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular
components of the cell cycle and inhibit T cell proliferation. Sci Signal. 2012;5:ra46. DOI PubMed PMC
80. Barkal AA, Brewer RE, Markovic M, et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
Nature. 2019;572:392-6. DOI PubMed PMC
81. Zeng S, Wang J, Kang H, Li H, Peng X, Yoon J. Photon-driven dye induction pyroptosis: an emerging anti-tumor immunotherapy
paradigm. Angew Chem Int Ed Engl. 2025;64:e202417899. DOI PubMed
82. Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15:486-99. DOI PubMed PMC
83. Reina-Campos M, Scharping NE, Goldrath AW. CD8 T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21:718-38.
+
DOI PubMed PMC
84. Wu H, Zhao X, Hochrein SM, et al. Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells
through HIF-1α-mediated glycolytic reprogramming. Nat Commun. 2023;14:6858. DOI PubMed PMC
85. Bensaad K, Favaro E, Lewis CA, et al. Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after
hypoxia-reoxygenation. Cell Rep. 2014;9:349-65. DOI PubMed
86. Patsoukis N, Bardhan K, Chatterjee P, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis
and fatty acid oxidation. Nat Commun. 2015;6:6692. DOI PubMed PMC
87. Bengsch B, Johnson AL, Kurachi M, et al. Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor
PD-1 are an early driver of CD8 T cell exhaustion. Immunity. 2016;45:358-73. DOI PubMed PMC
+
88. Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer.
2008;8:851-64. DOI PubMed
89. He J, Zhou Y, Sun L. Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to
Immunotherapy. Cell Commun Signal. 2024;22:89. DOI PubMed PMC
90. Ma S, Zhao Y, Lee WC, et al. Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer
immune effector dysfunction and resistance to anti-PD-1 immunotherapy. Nat Commun. 2022;13:4118. DOI PubMed PMC
24

