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Page 24 of 28                                               Cheng et al. Cancer Drug Resist. 2025;8:46




               65.  Xu Y, Wang X, Liu L, Wang J, Wu J, Sun C. Role of macrophages in tumor progression and therapy (Review). Int J Oncol. 2022;60:57.
                  DOI PubMed PMC
               66.  Xu Y, Zeng H, Jin K, et al. Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and
                  therapeutic vulnerability in patients with muscle-invasive bladder cancer. J Immunother Cancer. 2022;10:e003416. DOI PubMed PMC
               67.  Xue VW, Chung JY, Córdoba CAG, et al. Transforming growth factor-β: a multifunctional regulator of cancer immunity. Cancers.
                  2020;12:3099. DOI PubMed PMC
               68.  Viola A, Munari F, Sánchez-Rodríguez R, Scolaro T, Castegna A. The metabolic signature of macrophage responses. Front Immunol.
                  2019;10:1462. DOI PubMed PMC
               69.  Xiao L, Wang Q, Peng H. Tumor-associated macrophages: new insights on their metabolic regulation and their influence in cancer
                  immunotherapy. Front Immunol. 2023;14:1157291. DOI PubMed PMC
               70.  Bied M, Ho WW, Ginhoux F, Blériot C. Roles of macrophages in tumor development: a spatiotemporal perspective. Cell Mol Immunol.
                  2023;20:983-92. DOI PubMed PMC
               71.  Wu Q, Zhou W, Yin S, et al. Blocking triggering receptor expressed on myeloid cells-1-positive tumor-associated macrophages induced
                  by hypoxia reverses immunosuppression and anti-programmed cell death ligand 1 resistance in liver cancer. Hepatology.
                  2019;70:198-214. DOI PubMed PMC
               72.  Lubitz GS, Brody JD. Not just neighbours: positive feedback between tumour-associated macrophages and exhausted T cells. Nat Rev
                  Immunol. 2022;22:3. DOI PubMed
               73.  Kersten K, Hu KH, Combes AJ, et al. Spatiotemporal co-dependency between macrophages and exhausted CD8  T cells in cancer.
                                                                                              +
                  Cancer Cell. 2022;40:624-38.e9. DOI PubMed PMC
               74.  Nixon BG, Kuo F, Ji L, et al. Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in
                  cancer. Immunity. 2022;55:2044-58.e5. DOI PubMed PMC
               75.  Nagaraj S, Gupta K, Pisarev V, et al. Altered recognition of antigen is a mechanism of CD8  T cell tolerance in cancer. Nat Med.
                                                                                 +
                  2007;13:828-35. DOI PubMed PMC
               76.  Li J, Wang L, Chen X, et al. CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in
                  patients with non-small cell lung cancer. OncoImmunology. 2017;6:e1320011. DOI PubMed PMC
               77.  Hoskin D, Mader J, Furlong S, Conrad D, Blay J. Inhibition of T cell and natural killer cell function by adenosine and its contribution to
                  immune evasion by tumor cells (Review). Int J Oncol. 2008;32:527-35. PubMed
               78.  Xu S, Wang C, Yang L, et al. Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy. Front
                  Immunol. 2023;14:1199631. DOI PubMed PMC
               79.  Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular
                  components of the cell cycle and inhibit T cell proliferation. Sci Signal. 2012;5:ra46. DOI PubMed PMC
               80.  Barkal AA, Brewer RE, Markovic M, et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
                  Nature. 2019;572:392-6. DOI PubMed PMC
               81.  Zeng S, Wang J, Kang H, Li H, Peng X, Yoon J. Photon-driven dye induction pyroptosis: an emerging anti-tumor immunotherapy
                  paradigm. Angew Chem Int Ed Engl. 2025;64:e202417899. DOI PubMed
               82.  Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15:486-99. DOI PubMed PMC
               83.  Reina-Campos M, Scharping NE, Goldrath AW. CD8  T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21:718-38.
                                                      +
                  DOI PubMed PMC
               84.  Wu H, Zhao X, Hochrein SM, et al. Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells
                  through HIF-1α-mediated glycolytic reprogramming. Nat Commun. 2023;14:6858. DOI PubMed PMC
               85.  Bensaad K, Favaro E, Lewis CA, et al. Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after
                  hypoxia-reoxygenation. Cell Rep. 2014;9:349-65. DOI PubMed
               86.  Patsoukis N, Bardhan K, Chatterjee P, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis
                  and fatty acid oxidation. Nat Commun. 2015;6:6692. DOI PubMed PMC
               87.  Bengsch B, Johnson AL, Kurachi M, et al. Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor
                  PD-1 are an early driver of CD8  T cell exhaustion. Immunity. 2016;45:358-73. DOI PubMed PMC
                                       +
               88.  Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer.
                  2008;8:851-64. DOI PubMed
               89.  He J, Zhou Y, Sun L. Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to
                  Immunotherapy. Cell Commun Signal. 2024;22:89. DOI PubMed PMC
               90.  Ma S, Zhao Y, Lee WC, et al. Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer
                  immune effector dysfunction and resistance to anti-PD-1 immunotherapy. Nat Commun. 2022;13:4118. DOI PubMed PMC
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