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Li. Ageing Neur Dis 2023;3:17 Ageing and
DOI: 10.20517/and.2023.24
Neurodegenerative
Diseases

Editorial Open Access

Animal models for research on neurodegenerative
diseases

Xiao-Jiang Li

Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration,
Jinan University, Guangzhou 510632, Guangdong, China.
Correspondence to: Prof. Xiao-Jiang Li, Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-
Macau Institute of CNS Regeneration, Jinan University, 601 Huangpu Blvd W, Tianhe District, Guangzhou 510632, Guangdong,
China. E-mail: xjli33@jnu.edu.cn

How to cite this article: Li XJ. Animal models for research on neurodegenerative diseases. Ageing Neur Dis 2023;3:17.
https://dx.doi.org/10.20517/and.2023.24

Received: 27 Jun 2023 Accepted: 24 Aug 2023 Published: 28 Aug 2023

Academic Editors: Weidong Le, Zhentao Zhang, David Finkelstein Copy Editor: Lin He Production Editor: Lin He

Animal models play a crucial role in investigating neurodegenerative diseases and developing effective
treatments. Genetically modified rodents have been extensively utilized to model neurodegenerative
diseases, providing valuable insights into disease pathogenesis. More recently, the advent of the gene-editing
tool CRISPR-Cas9 has enabled the creation of large animal models (such as rabbits, pigs, and monkeys) that
can replicate important pathological features observed in human brains. This Special Issue aims to explore
the strengths and limitations of animal models from various species and provide an overview of their utility
in advancing our understanding of neurodegenerative disease pathogenesis and the development of effective
therapies.

In a Special Issue on the topic of “Animal Models of Different Species for Investigating Neurodegenerative
Diseases”, four articles were included that described animal models, different from the commonly used
mouse models, for studying neurodegenerative diseases (NDs). These articles focused on genetically
modified large animals and emphasized their value in modeling NDs.

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
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