Cancers doi: 10.20517/mns.2025.05

Authors: Ruiming Liu,Qin Yue

Implantable bioelectronic devices are key to intervening in neurological diseases and realizing brain-computer interfaces. Ideal devices should possess mechanical properties that match biological tissues to reduce rejection reactions and support dynamic control after implantation to enhance monitoring flexibility. Recently, a controllable soft microfiber inspired by earthworms was reported. This microfiber is self-encapsulated into a one-dimensional fiber structure through a two-dimensional thin-film electrode, integrating multi-channel sensing capabilities for simultaneous monitoring of electroencephalogram and muscle mechanical signals. Unlike conventional passive implantable fibers that remain stationary after implantation, this fiber achieves magnetically controlled movement by embedding magnetic particles, enabling dynamic navigation within cortical or muscular tissues and maintaining long-term stability (over 43 weeks). However, its clinical translation still faces challenges such as precision in motor control, long-term signal stability, and complex manufacturing processes. Future research should focus on closed-loop control systems, material optimization, and multifunctional integration to promote the application of such dynamic intelligent implantable devices in neural rehabilitation and personalized medicine.